24 May 2022
: Case report 
A 62-Year-Old Man Presenting with Bilateral Tremor of the Upper Limb After a Diagnosis of COVID-19 with Confirmed Volumetric Brain Loss
Unusual clinical course, Challenging differential diagnosis
Sachin M. Bhagavan1CDEF*, Swathi Beladakere Ramaswamy1DEF, Tejas R. Mehta1EF, Raghav Govindarajan1ADEF, Joseph Cousins2CDEFDOI: 10.12659/AJCR.934955
Am J Case Rep 2022; 23:e934955
Table 1. Volumes of cerebral spinal fluid, white matter, the mesencephalon, third ventricle, and cerebellum calculated by Siemens Healthineers brain volumetric analysis, NeuroQuant, shows significant short-term increased cerebral spinal fluid and decreased white matter volume, indicating volume loss.
| Volume (ml) | Initial MRI | 2 months post COVID-19 MRI | mL difference | % difference from initial exam |
|---|---|---|---|---|
| CSF | 358 ml | 392 ml | 34 ml | 9.5% |
| White matter | 507 ml | 471 ml | 36 ml | 7.1% |
| Mesencephalon | 9.8 ml | 9.7 ml | 0.1 ml | 1% |
| 3 ventricle | 1.8 ml | 1.7 ml | 0.1 ml | 5.5% |
| Cerebellum | 103.1 ml | 104.5 ml | 1.4 ml | 0.013% |
| CSF – cerebrospinal fluid. | ||||