10 January 2022
: Case report 
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV) Registry
Unusual clinical course, Unusual or unexpected effect of treatment
Christian Schumann1ABCDEFG, Franz Heigl2BDE, Imanuel J. Rohrbach3BCDEF, Ahmed Sheriff45ABDE, Lutz Wagner6BCDE, Florian Wagner6CDEF, Jan Torzewski3ABCDEFG*DOI: 10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
Table 1. Patient characteristics.
| Patient | Age | Sex | Concomitant diseases | Duration of symptoms before hospital admission (d) | Oxygen supply, intubation, ventilation duration (d) | Hospital length of stay (d) | PCR, C(t), mutation analysis | Antibiotic therapy | Further issues |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 37 | F | Immune deficiency, multiple sclerosis | ca. 21 | 5 (NIV) | 7 | SARS-CoV-2-VOC, C(t) 28.2, B.1.1.7 (Alpha) | .. | COVID reactivation under Rituximab therapy |
| 2 | 60 | M | Arterial hypertension, coronary heart disease, obesity, DM type II | 2 | 16 (NIV) | 15 | SARS-CoV-2-VOC, C(t) 25.8, B.1.617.2 (Delta) | .. | .. |
| 3 | 57 | M | Arterial hypertension, emphysema | 11 | 9 (NIV) | 9 | SARS-CoV-2-VOC, C(t) 31.5, B.1.617.2 (Delta) | From d 1 to d 6 | .. |
| 4 | 54 | M | Arterial hypertension, obesity | 9 | 10 (NIV) | 9 | SARS-CoV-2, no mutation analysis | .. | .. |
| 5 | 57 | F | Coronary heart disease, ischemic cardiomyopathy, allergic diathesis | 7 | 4 (intubation), 7 (NIV) | 21 (15-21: social reasons) | SARS-CoV-2-VOC, C(t) 25.2, B.1.617.2 (Delta) | From d 11 to d 17 | Secondary bacterial pneumonia (from d 11 onwards) |
| 6 | 58 | M | .. | 0 | 8 (Intubation), 12 (NIV) | 21 | SARS-CoV-2-VOC, C(t) 19.9, B.1.617.2 (Delta) | From d 3 to d 8 and from d 9 to d 21 | pneumonia, anxious depressive adjustment disorder under COVID pneumonia |
| 7 | 43 | M | Sleep apnoea syndrome, arterial hypertension | 8 | 8 (NIV) | 8 | SARS-CoV-2-VOC, C(t) 28.2, B.1.617.2 (Delta) | .. | .. |
| Table shows age, sex, concomitant diseases, respiratory supply, hospital length of stay, PCR, antibiotic therapy and further issues in our 7 patients. All patients had documented SARS-CoV-2-induced pneumonia and respiratory failure. DM – diabetes mellitus; C(t) – crossing threshold; PCR – polymerase chain reaction; SARS-CoV-2-VOC – severe-acute-respiratory-syndrome-coronavirus-2-variant of concern). | |||||||||