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04 March 2022: Articles

Dramatic Response to Trastuzumab Deruxtecan Rechallenge in a Patient with HER2-Positive Gastric Cancer: A Case Report

Unusual setting of medical care

Takatsugu Ogata A , Yasuko Fujita B , Kei Muro A*

DOI: 10.12659/AJCR.935600

Am J Case Rep 2022; 23:e935600

Table 2. Laboratory data on the administration of T-DXd.

HematologyNormal range
White blood cell13060/μL3300–8600
Neutrophil79.0%
Eosinophil3.5%
Basophil0.0%
Monophil9.0%
Lymphocyte8.5%
Red blood cell451×10/μL386–492×10
Hemoglobin9.4 g/dL11.6–14.8
Platelet38.3×10/μL15.8–34.8×10
ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Ca – calcium; CA19-9 – carbohydrate antigen 19-9; CA125 – cancer antigen 125; CEA – carcinoembryonic antigen; CRP – C-reactive protein; K – potassium; LDH – lactate dehydrogenase; Na – sodium; T-DXd – trastuzumab deruxtecan.
Tumor markerNormal range
CEA2.3 ng/mL
CA19-942.2 U/mL
CA12561.0 U/mL
ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Ca – calcium; CA19-9 – carbohydrate antigen 19-9; CA125 – cancer antigen 125; CEA – carcinoembryonic antigen; CRP – C-reactive protein; K – potassium; LDH – lactate dehydrogenase; Na – sodium; T-DXd – trastuzumab deruxtecan.
BiochemistryNormal range
Total protein6.0 g/dL6.7–8.3
Albumin3.3 g/dL4.0–5.0
Total bilirubin0.5 mg/dL0.3–1.2
AST10 U/L13–33
ALT6 U/L6–27
LDH156 U/L119–229
BUN16.7 mg/dL8–22
Creatinine1.00 mg/dL0.40–0.70
Na138 mmol/L138–146
K3.7 mmol/L3.6–4.9
Ca8.2 mg/dL8.7–10.3
CRP4.23 mg/dL
ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Ca – calcium; CA19-9 – carbohydrate antigen 19-9; CA125 – cancer antigen 125; CEA – carcinoembryonic antigen; CRP – C-reactive protein; K – potassium; LDH – lactate dehydrogenase; Na – sodium; T-DXd – trastuzumab deruxtecan.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923