04 March 2022
: Case report 
Dramatic Response to Trastuzumab Deruxtecan Rechallenge in a Patient with HER2-Positive Gastric Cancer: A Case Report
Unusual setting of medical care
Takatsugu Ogata1ABCDEF, Yasuko Fujita
2BCD, Kei Muro1ABCDE*
DOI: 10.12659/AJCR.935600
Am J Case Rep 2022; 23:e935600
Table 2. Laboratory data on the administration of T-DXd.
| Hematology | Normal range | |
|---|---|---|
| White blood cell | 13060/μL | 3300–8600 |
| Neutrophil | 79.0% | |
| Eosinophil | 3.5% | |
| Basophil | 0.0% | |
| Monophil | 9.0% | |
| Lymphocyte | 8.5% | |
| Red blood cell | 451×10/μL | 386–492×10 |
| Hemoglobin | 9.4 g/dL | 11.6–14.8 |
| Platelet | 38.3×10/μL | 15.8–34.8×10 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Ca – calcium; CA19-9 – carbohydrate antigen 19-9; CA125 – cancer antigen 125; CEA – carcinoembryonic antigen; CRP – C-reactive protein; K – potassium; LDH – lactate dehydrogenase; Na – sodium; T-DXd – trastuzumab deruxtecan. | ||
| Tumor marker | Normal range | |
| CEA | 2.3 ng/mL | <5.0 |
| CA19-9 | 42.2 U/mL | <37.0 |
| CA125 | 61.0 U/mL | <26.9 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Ca – calcium; CA19-9 – carbohydrate antigen 19-9; CA125 – cancer antigen 125; CEA – carcinoembryonic antigen; CRP – C-reactive protein; K – potassium; LDH – lactate dehydrogenase; Na – sodium; T-DXd – trastuzumab deruxtecan. | ||
| Biochemistry | Normal range | |
| Total protein | 6.0 g/dL | 6.7–8.3 |
| Albumin | 3.3 g/dL | 4.0–5.0 |
| Total bilirubin | 0.5 mg/dL | 0.3–1.2 |
| AST | 10 U/L | 13–33 |
| ALT | 6 U/L | 6–27 |
| LDH | 156 U/L | 119–229 |
| BUN | 16.7 mg/dL | 8–22 |
| Creatinine | 1.00 mg/dL | 0.40–0.70 |
| Na | 138 mmol/L | 138–146 |
| K | 3.7 mmol/L | 3.6–4.9 |
| Ca | 8.2 mg/dL | 8.7–10.3 |
| CRP | 4.23 mg/dL | <0.30 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; Ca – calcium; CA19-9 – carbohydrate antigen 19-9; CA125 – cancer antigen 125; CEA – carcinoembryonic antigen; CRP – C-reactive protein; K – potassium; LDH – lactate dehydrogenase; Na – sodium; T-DXd – trastuzumab deruxtecan. | ||