A Case of a Rare Parathyroid Hormone (PTH)-Producing Neuroendocrine Tumor

18 July 2022: Articles

Challenging differential diagnosis, Rare disease

Catherine Dianne Quinn ^A* , Fihr Chaudhary ^A , Aron Gould-Simon ^B , Baorong Chen ^B , Harsimran Singh Bhandal ^B , Uzair Chaudhary ^A

DOI: 10.12659/AJCR.935783

Am J Case Rep 2022; 23:e935783

Table 1. Summary of previously reported ectopic parathyroid hormone (PTH) secretion in the gastrointestinal tract.

Authors	Year	Age (yr)/sex	Nodal/visceral metastasis	Ectopic hormone production	Treatment	Survival	Ectopic PTH origin
Kwon et al []⁶	2018	44	Not reported	Elevated PTH	Chemotherapy; renal replacement therapy	Deceased	Combined hepatocellular carcinoma and neuroendocrine carcinoma
Nakajima et al []⁷	2013	70/M	Present (liver region)	Elevated PTH	Chemotherapy	Deceased	Primary and metastatic gastric carcinomas
VanHouten et al []⁸	2006	74/W	Present (liver/lymph nodes)	Elevated PTH	IV bisphosphonates, calcitonin, forced saline diuresis	Deceased	Pancreatic malignancy
Mahoney et al []⁹	2006	72/M	Not reported	Elevated PTH	Trans-arterial chemoembolization	Deceased	Hepatocellular carcinoma
Koyama et al []¹⁰	1999	83/M	Absent	Elevated PTH	Transcatheter arterial embolization	Alive (F/U 24 months)	Hepatocellular carcinoma
Grajower et al []¹¹	1976	80/M	Present (lymph nodes)	Elevated PTH	N/A	Deceased	Esophageal Carcinoma
Robin et al []¹²	1976	66/M	Present	Elevated PTH, elevated urinary cyclic AMP	NA	Deceased	Small intestine leiomyosarcoma
Deftos et al []¹³	1976	37	Absent	Elevated PTH and calcitonin, pro-insulin and insulin	Calcium infusion before and after streptozotocin therapy	Deceased	Pancreatic islet cell carcinoma
Deftos et al []¹³	1976	23	Present	Elevated PTH and calcitonin	P-chlorophenyl- alanine and melphalen	Deceased (OS: 18 months)	Gastric carcinoid
Palmieri et al []¹⁴	1974	NA	Present	Elevated PTH	Surgery	NA	Pancreatic islet cell carcinoma (liver metastases)