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14 May 2022: Articles

Case Series of Successful Intravenous Immunoglobulin (IVIG) Treatment in 4 Pregnant Patients with Severe COVID-19-Induced Hypoxia

Unusual or unexpected effect of treatment, Rare disease

Matthew Geriak A* , Dominic McGrosso D , David J. Gonzalez D , Matthew Dehner A , George Sakoulas A

DOI: 10.12659/AJCR.936734

Am J Case Rep 2022; 23:e936734

Table 1. Summary of clinical characteristics of 4 pregnant patients with severe or critical COVID-19 receiving IVIG (Privigen®) therapy.

Point of pregnancy*Hospital day IVIG givenLength of hospital stayDuration of APACH II mechanical ventilationScore*A-a Gradient*BMI* (kg/m2)CRP* (mg/L)D-dimer (ng/mL)PMN/lymph ratio*Pregnancy outcome
1.26 wk5–721 days11 days (HD 4–14)933034.685.08968.0NSVD, 37.5 wk
2.17 wk1–39 days8 days (HD 4–11)759828.0133.291511.6NSVD, 38 wk
3.35 wk2–48 daysNone931041.191.652264.1C-section, 35 wk HD 3
4.35 wk1–312 days4 days (HD 1–4)1656538.4117.213785.8C-section, 35 wkHD 1
* At time of IVIG initiation. A-a – Alveolar-arterial; BMI – body mass index; CRP – C-reactive protein (normal level

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923