08 July 2022: Articles
Clinical Outcomes of Sotrovimab Treatment in 10 High-Risk Patients with Mild COVID-19: A Case Series
Unusual or unexpected effect of treatment
Kenichiro Takeda A* , Hajime Kasai A , Seiichiro Sakao A , Mikihito Saito A , Kohei Shikano A , Akira Naito A , Mitsuhiro Abe B , Takeshi Kawasaki A , Misuzu Yahaba A , Toshibumi Taniguchi A , Hidetoshi Igari A , Takuji Suzuki ADOI: 10.12659/AJCR.936832
Am J Case Rep 2022; 23:e936832
Table 1. Baseline demographic and disease characteristics of patients.
| Case | Age, Sex | Underlying medical condition | BMI (kg/m 2) | No. of risk factors* | Vaccination (type) | Symptoms | CT findings in lung | Days from onset to sotrovimab administration | Days from onset to symptom improvement | Adverse events |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 60s, male | Normal | 25.9 | 1 | Twice (mRNA) | Sore throat | No pneumonia | 2 | 3 | None |
| 2 | 30s, male | Lung cancer | 21 | 1 | Twice (mRNA) | Fever | No pneumonia | 5 | 11 | None |
| 3 | 30s, male | Cardiomyopathy (post LVAD implantation) | 22.8 | 1 | twice (mRNA) | Fever, cough, sore throat | No pneumonia | 5 | 5 | None |
| 4 | 30s, male | Cardiomyopathy (post LVAD implantation) hyperlipidemia | 21 | 2 | Twice (mRNA) | Fever, cough | No pneumonia | 5 | 6 | None |
| 5 | 40s, male | Chronic kidney disease (on hemodialysis) diabetes, cytopenia | 29.1 | 2 | None | Fever, sore throat | No pneumonia | 4 | 7 | None |
| 6 | 40s, male | IgA nephropathy (post kidney | 23.4 | 3 | Twice (mRNA) | Fever, sore throat | No pneumonia | 2 | 15 | Skin rash |
| 7 | 50s, female | transplantation) Lung cancer | 24.4 | 2 | Twice (mRNA) | Fever, sore throat | No pneumonia | 2 | 6 | None |
| 8 | 30s, male | Acquired immunodeficiency syndrome, nontuberculous mycobacteriosis | 20.5 | 1 | Twice (mRNA) | Fever | No pneumonia | 2 | 2 | None |
| 9 | 80s, female | Autoimmune hemolytic anemia, asthma, sleep apnea syndrome | 33.7 | 4 | Twice (mRNA) | Fever, cough | No pneumonia | 3 | 5 | None |
| 10 | 40s, male | Cardiomyopathy (post heart transplantation) diabetes, hyperlipidemia, chronic kidney disease | 30 | 6 | None | Fever, cough fatigue, nausea | No pneumonia | 2 | 3 | None |
| * Denotes risk factors: Age ≥55 yr; diabetes for which medication was warranted; obesity (BMI >30); chronic kidney disease; congestive heart failure: NYHA class II, III, or IV; chronic obstructive pulmonary disease; and moderate-to-severe asthma. BMI – body mass index, LVAD – left-ventricular-assist-device. | ||||||||||