Inhaled Nitric Oxide in Acute Severe Pulmonary Hypertension and Severe Acute Respiratory Distress Syndrome Secondary to COVID-19 Pneumonia: A Case Report

25 October 2022: Articles

Challenging differential diagnosis, Unusual setting of medical care, Rare disease

Marc Vives ^A* , Iñaki Gascó ^B , Guillem Pla ^B , Jorge Luis Maciel ^B , Ana Ricart Hernandez ^B , Kevin Regí Roman ^B , Fina Parramon ^B

DOI: 10.12659/AJCR.937147

Am J Case Rep 2022; 23:e937147

Table 2. Laboratory analysis during inhaled nitric oxide treatment period.

	D0 before iNO	D1 after iNO	D2 after iNO	D3 after iNO	D4 after iNO
PaO2/FiO2 (mmHg)	100	216	234	140	170
Ventilatory mode	VC	VC	PS	CPAP	PS
Leukocyte (×10/L)	14.3	10.1	13	16	17
CRP (mg/L)	10.38	4.21	2.47	2.45	2.4
Hb (g/dL)	9.4	8.8	9.5	9.3	8.8
Platelets (×10/L)	426	495	591	602	561
FBG (mg/dL)	1061	892	770	725	710
PCT (ng/mL)
CPAP – continuous positive airway pressure; CRP – C-reactive protein; D0 – day 0; D1 – day 01; D2 – day 2; D3 – day 3; D4 – day 4; D5 – day 5; D6 – day 6; D7 – day 7; D8 – day 8; D9 – day 9; D10 – day 10; FBG – fibrinogen; Hb – hemoglobin; iNO – inhaled nitric oxide; PCT – procalcitonin; PS – pressure support; VC – volume controlled.
	D5 after iNO	D6 after iNO	D7 after iNO	D8 STOP iNO	D9	D10
PaO2/FiO2 (mmHg)	124	192	321	315	200	190
Ventilatory mode	PS	PS	PS	PS	VC	VC
Leukocyte (×10/L)	17.8	18	21	22	18	21
CRP (mg/L)	2.4	2.4	2.55	16.7	7.7	3.7
Hb (g/dL)	8.6	8.8	9	7.7	8	8.7
Platelets (×10/L)	513	518	618	442	468	611
FBG (mg/dL)	700	690	680	820	744	756
PCT (ng/mL)				0.03	0.04	0.05
CPAP – continuous positive airway pressure; CRP – C-reactive protein; D0 – day 0; D1 – day 01; D2 – day 2; D3 – day 3; D4 – day 4; D5 – day 5; D6 – day 6; D7 – day 7; D8 – day 8; D9 – day 9; D10 – day 10; FBG – fibrinogen; Hb – hemoglobin; iNO – inhaled nitric oxide; PCT – procalcitonin; PS – pressure support; VC – volume controlled.