Diagnostic Pitfalls of Chylothorax After Dasatinib Treatment of Chronic Myeloid Leukemia

29 November 2022: Articles

Unknown etiology, Mistake in diagnosis, Adverse events of drug therapy

Ryan L. Kelly ^E* , Ju Young Bae ^E , Samantha D’Annunzio ^E , Francesca Montanari ^D

DOI: 10.12659/AJCR.938319

Am J Case Rep 2022; 23:e938319

Table 2. Review of cases associated with Dasatinib-induced chylothorax and outcomes.

Age	Gender	Months on dasatinib	Previous therapy	Treatment	Dasatinib status	Recurrence of PE	Citation Huang et al
40	Female	40	Imatinib	Diuretics + steroids	Stopped	None	[]³
73	Female	12	None	Diuretics + initiation of herbal medicine, goreisan, after trialing bosutinib and imatinib)	Stopped (changed to imatinib)	None	Sasaki et al []⁴
63	Female	48	None	Nebulizers, steroids, doxycycline, ceftriaxone, and lasix	Stopped (changed to nilotinib)	Recurrences until switched to nilotinib	Al-Abcha et al []⁵
69	Male	10	Imatinib and Nilotinib	Change to bosutinib	Stopped (changed to bosutinib)	None	Baloch et al []⁶
5	Female	10	Imatinib	Complete stopping of dasatinib	Stopped	None	Hickman et al []⁷
51	Male	50	Imatinib	Steroids + nilotinib	Stopped (switched to nilotinib)	None	Hsu et al []⁸
71	Woman	2	Imatinib	Thoracentesis, dose reducing dasatinib	Dose reduction	Reduced incidence, not complete resolution	Ferreiro et al []⁹
47	Male	8	Imatinib	Thoracentesis, diuretics, supportive tx	Continued	Unclear	Yang et al []¹⁰
46	Male	19	Imatinib	Discontinue dasatinib, thoracentesis, diuretics, + steroids	Stopped	Unclear	Yang et al []¹⁰
49	Male	26	Imatinib	Dasatinib temporarily stopped, ligation of thoracic duct, parenteral nutrition support	Stopped for 48 hrs, now back on dasatinib	Unclear	Yang et al []¹⁰
71	Male	6	Imatinib	Dasatinib stopped	Stopped	None	Chen et al []¹¹
63	Woman	12	None	Thoracentesis, prednisone, imatinib	Stopped (switched to imatinib)	None	Molina et al []¹²