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03 April 2023: Articles

A Case of Lupus Nephritis Preceded by Minimal Change Disease and Membranous Glomerulonephritis

Unusual clinical course, Mistake in diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents

Fengxia Zhang A , Nan Jiang B , Karthick Kumaran Munisamy Selvam B , Bohou Li B , Qiong Wu B , Sichun Wen B , Ruiquan Xu D* , Shuangxin Liu A

DOI: 10.12659/AJCR.938402

Am J Case Rep 2023; 24:e938402

Table 1. Pathological characteristics of the 3 renal biopsies.

ParametersFirst renal biopsySecond renal biopsyThird renal biopsy
Pathological diagnosisMinimal change glomerulopathyMembranous nephropathy (II period)Membranous lupus nephritis
IgA in renal biopsyNegativenegative2+, GCW and mesangium
IgG in renal biopsyNegative3+, GCW3+, GCW and mesangium
IgM in renal biopsyNegativenegative2+, GCW and mesangium
C3 in renal biopsyNegative2+, GCW3+, GCW and mesangium
C1q in renal biopsyNegative1–2+, GCW3+, GCW and mesangium
IgG1 in renal biopsy2+, GCW3+, GCW and mesangium
IgG2 in renal biopsy2+, GCW and mesangium
IgG3 in renal biopsy2+, GCW and mesangium
IgG4 in renal biopsy2+, GCW
κ in renal biopsy+−+, GCW and mesangium
λ in renal biopsy++, GCW and mesangium
PLA2R in renal biopsy
GCW glomerular capillary walls’; “∼” specific laboratory test not done; “−” negative

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923