31 December 2022
: Case report 
A 75-Year-Old Woman with a 5-Year History of Controlled Type 2 Diabetes Mellitus Presenting with Polydipsia and Polyuria and a Diagnosis of Central Diabetes Insipidus
Rare coexistence of disease or pathology
Nobumasa Ohara1ABCDEF*, Toshinori Takada2D, Yasuhiro Seki3D, Katsuhiko Akiyama3D, Yuichiro Yoneoka
3BCD
DOI: 10.12659/AJCR.938482
Am J Case Rep 2022; 23:e938482
Table 3. Summary of reported cases of central diabetes insipidus (CDI) that developed in patients with treated type 2 diabetes mellitus (T2D).
| Ref. | Age (years) | Sex | Duration of T2D (years) | HbA1c (%) | Plasma glucose (mg/dL) | Diabetic retinopathy | Medication for T2D | Symptoms |
|---|---|---|---|---|---|---|---|---|
| []10 | 48 | F | 2 | N.D. | N.D. | N.D. | Insulin | Thirst, polydipsia, polyuria |
| []11 | 46 | F | 10 | 10.7 | 351 | N.D. | Insulin | Polydipsia, polyuria |
| Present case | 75 | F | 5 | 6.6 | 114 | Negative | OHAs | Thirst, polydipsia, polyuria |
| HbA1c – glycated hemoglobin; MRI – magnetic resonance imaging; N.D. – not determined; OHA – oral hypoglycemic agent; Posm – plasma osmolality; Uosm – urinary osmolality. | ||||||||
| Ref. | Urine volume (L/day) | Urine specific gravity | Uosm (mOsm/kg) | Posm (mOsm/kg) | Anterior pituitary dysfunction | Morphological pituitary abnormality on MRI | Treatment for CDI | Other findings |
| []10 | 9.7 | 1.005 | 106 | 291 | Negative | None | Nasal DDAVP | Bronchial asthma |
| []11 | 5 | 1.008 | 138 | 285 | Negative | None | DDAVP | None |
| Present case | 6.3 | 1.002 | 67 | 315 | Negative | None | Oral DDAVP | Chronic autoimmune thyroiditis |
| HbA1c – glycated hemoglobin; MRI – magnetic resonance imaging; N.D. – not determined; OHA – oral hypoglycemic agent; Posm – plasma osmolality; Uosm – urinary osmolality. | ||||||||