A 75-Year-Old Woman with a 5-Year History of Controlled Type 2 Diabetes Mellitus Presenting with Polydipsia and Polyuria and a Diagnosis of Central Diabetes Insipidus

31 December 2022: Articles

Rare coexistence of disease or pathology

Nobumasa Ohara ^A* , Toshinori Takada ^D , Yasuhiro Seki ^D , Katsuhiko Akiyama ^D , Yuichiro Yoneoka ^B

DOI: 10.12659/AJCR.938482

Am J Case Rep 2022; 23:e938482

Table 3. Summary of reported cases of central diabetes insipidus (CDI) that developed in patients with treated type 2 diabetes mellitus (T2D).

Ref.	Age (years)	Sex	Duration of T2D (years)	HbA1c (%)	Plasma glucose (mg/dL)	Diabetic retinopathy	Medication for T2D	Symptoms
[]¹⁰	48	F	2	N.D.	N.D.	N.D.	Insulin	Thirst, polydipsia, polyuria
[]¹¹	46	F	10	10.7	351	N.D.	Insulin	Polydipsia, polyuria
Present case	75	F	5	6.6	114	Negative	OHAs	Thirst, polydipsia, polyuria
HbA1c – glycated hemoglobin; MRI – magnetic resonance imaging; N.D. – not determined; OHA – oral hypoglycemic agent; Posm – plasma osmolality; Uosm – urinary osmolality.
Ref.	Urine volume (L/day)	Urine specific gravity	Uosm (mOsm/kg)	Posm (mOsm/kg)	Anterior pituitary dysfunction	Morphological pituitary abnormality on MRI	Treatment for CDI	Other findings
[]¹⁰	9.7	1.005	106	291	Negative	None	Nasal DDAVP	Bronchial asthma
[]¹¹	5	1.008	138	285	Negative	None	DDAVP	None
Present case	6.3	1.002	67	315	Negative	None	Oral DDAVP	Chronic autoimmune thyroiditis
HbA1c – glycated hemoglobin; MRI – magnetic resonance imaging; N.D. – not determined; OHA – oral hypoglycemic agent; Posm – plasma osmolality; Uosm – urinary osmolality.