08 May 2023
: Case report 
Anti-PL12 Anti-Synthetase Syndrome and Amyotrophic Lateral Sclerosis: A Case Report of a Rare Comorbidity
Rare coexistence of disease or pathology
Ejaz A. Shamim12ABCDEF*, Melvin W. Kong1BD, Ivan Y. Lim3BE, Richard J. McCarthy1BD, Sharday N. Grant4BDEF, Harpreet K. Nagi5BDEDOI: 10.12659/AJCR.939035
Am J Case Rep 2023; 24:e939035
Table 1. Summary of the clinical serological test results.
| Type of testing performed (normal reference) | Results range (N=number of repeat tests) | Results average |
|---|---|---|
| Creatine Kinase (39–308 U/L) | 298–1292 (N=26) | 696.3 |
| Aldolase (≤8.1 U/L) | 15.3–22.1 (N =2) | 22.1 |
| ESR (0–20 mm/hr) | 16–33 (N=4) | 27.75 |
| CRP (≤5 mg/L) | 1.5–10.9 (N=16) | 3.8625 |
| ANA (negative) | Positive, Negative, Negative (N=3) | |
| RF (<14 IU/mL) | 7–8 (N=1) | 7.5 |
| CCP (≤4.9 U/mL) | 2.9–7.5 (N=3) | 5.4 |
| DNA DS AB (≤4 IU/mL) | 1 (N=3) | 1 |
| Smith antibody (<1.0 IU/mL) | <1.0 (N=3) | <1.0 |
| Smith ab+RNP IGG (<1.0 IU/mL) | <1.0 (N=3) | <1.0 |
| SS-A antibody (≤1.0 IU/mL) | >8 (N=3) | >8 |
| SS-B antibody (≤1.0 IU/mL) | <1.0 (N=3) | <1.0 |
| SCL-70 antibody (<1.0 AI) | <1.0 (N=3) | <1.0 |
| IgG (700–1600 mg/dL) | 1106 (N=1) | 1106 |
| IgM (40–230 mg/dL) | 87 (N=1) | 87 |
| IgA (70–400 mg/dL) | 148 (N=1) | 148 |
| PL-7 Autoantibodies (not detected) | Not detected (N=2) | Not detected |
| PL-12 Autoantibodies (not detected) | Detected (N=2) | Detected |
| Mi-2 Autoantibodies (not detected) | Not detected (N=2) | Not detected |
| Ku Autoantibodies (not detected) | Not detected (N=2) | Not detected |
| EJ Autoantibodies (not detected) | Not detected (N=2) | Not detected |
| OJ Autoantibodies (not detected) | Not detected (N=2) | Not detected |
| SRP Autoantibodies (not detected) | Not detected (N=2) | Not detected |
| Jo-1 Antibody (< 1.0 negative) | <1.0 negative (N=2) | <1.0 negative |