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25 May 2023: Articles

Severe Neutropenia and Hepatotoxicity After Carbimazole Drug Therapy for Hyperthyroidism in a Pediatric Patient: A Case Report

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)

Lina I. Alnajar A , Reem Alkahtani B , Malak A. Alasqah B , Abdelrahman Alanizi D , Nader Bin Sheraim E , Basma Alwahhabi E , Mohammed AlAboud E , Alaa A. Alhubaishi A*

DOI: 10.12659/AJCR.939331

Am J Case Rep 2023; 24:e939331

Table 1. Changes in laboratory data during admission and after discharge.

VariableNormal valuesOn admissionDay 2Day 3Day 4Day 5Day 6Day 55
Alanine aminotransferase0–35 U/L195 U/L134 U/L113 U/L99 U/L90 U/L81 U/L29 U/L
Aspartate aminotransferase0–35 U/L299 U/L194 U/L151 U/L125 U/L108 U/L91 U/L35 U/L
Alkaline phosphatase47–119 U/L89 U/L84 U/L76 U/L79 U/L90 U/L124 U/L93 U/L
Direct bilirubin0–3.4 µmol/L0.7 µmol/L0.7 µmol/L1.4 µmol/L0.9 µmol/L1 µmol/L0.8 µmol/L1.3 µmol/L
Total bilirubin5–21 µmol/L4.5 µmol/L5.9 µmol/L5.8 µmol/L6.8 µmol/L7 µmol/L5.6 µmol/L8 µmol/L
White blood cells4.00–12.00×10/L1.0×10/L0.90×10/L1.30×10/L7.10×10/L17.7×10/L23.50 ×10/L2.7×10/L
Neutrophils1.40–7.70×10/L0.37×10/L0.24×10/L0.16×10/L5.11×10/L13.61×10/L18.54×10/L0.57
Neutrophils%40–60%37%27%12%5.8%76.9%78.9%21%
Lymphocytes1.00–5.500.37×10/L0.58×10/L0.60×10/L1.07×10/L1.53×10/L3.04×10/L3.5×10/L2.0310/L
Lymphocytes%20–40%58%67%82%21.6%17.2%14.9%75%
Monocytes0.10–0.80×10/L0.03×10/L0.03×10/L0.05×10/L0.41×10/L0.92×10/L1.2×10/L0.1110/L
Monocytes%2–8%3%3%4%5.8%5.2%5.1%4%
Thyroid-stimulating hormone0.480–4.170 uIU/ml0.124 buIU/mlNA0.71 uIU/mlNANA0.05 uIU/ml0.05 uIU/ml
Free T410.70–18.40 pmol/L10.2 pmol/LNA11.3 pmol/LNANA12.70 pmol/L12.7 pmol/L

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923