16 May 2023: Articles
Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report
Challenging differential diagnosis, Unusual setting of medical care, Rare disease
Ji Yeon Kim D , Bomi Kim A*DOI: 10.12659/AJCR.939349
Am J Case Rep 2023; 24:e939349
Table 1. Summary of published cases of uterine leiomyosarcoma with rhabdoid features.
| Source | Age | Symptoms | Tumor marker | treatment | Site of the uterus | Recurrence or metastasis | Follow-up (time) |
|---|---|---|---|---|---|---|---|
| Yorulmaz 2007 []12 | 56 | Abdominal | CA125 and CEA: WNL | TH BSO palliative CT→mass excision, omentectomy, and left nephrectomy, adjuvant CT and RT | Uterine mass | Recurrence within 2 years | DOD (2 years) |
| Hiraizumi 2011 []23 | 36 | NA | CA125: ↑ | LEEP, adjuvant CT →TH BSO, CT | Uterus, pelvic cavity, uterus | Metastasis to urinary bladder, liver and spleen | DOD (22 months) |
| Chauhan 2017 []27 | 60 | Abdominal mass and dull lower abdominal pain | NA | TH BSO | Myometrium | NA | NA |
| Kubo 2017 []16 | 52 | Abdominal fullness | CA125 and CA19-9: WNL | TH, Adjuvant CT | Anterior wall of the uterine cervix | none | NED (3 months) |
| Chiang 2019 []14 | 43 (patient 1) | Abdominal mass | NA | Surgery, CT, and RT | NA | NA | AWD (180 months) |
| Chiang 2019 []14 | 36 (patient 2) | Painful menses, pelvic mass | NA | Surgery | NA | NA | NED (9 months) |
| Chiang 2019 []14 | 56 (patient 3) | Abdominal pain, pelvic pain | NA | Surgery | NA | NA | LTF |
| Chiang 2019 []14 | 42 (patient 4) | Symptomatic fibroids | NA | Surgery | NA | NA | NED (96 months) |
| Chiang 2019 []14 | 41 (patient 5) | Uterine mass | NA | Surgery | NA | NA | AWD (75 months) |
| Chiang 2019 []14 | 55 (patient 6) | Uterine mass | NA | Surgery | NA | NA | NED (1 months) |
| Chiang 2019 []14 | NA (patient 7) | Symptomatic fibroids | NA | Surgery | NA | NA | NA |
| Chiang 2019 []14 | 40 (patient 8) | NA | NA | Surgery, CT | NA | NA | NA |
| Chiang 2019 []14 | 82 (patient 9) | Uterine mass | NA | Surgery | NA | NA | LTF |
| Chiang 2019 []14 | 45 (patient 10) | Pelvic mass | NA | Surgery | NA | NA | NED (96 months) |
| Chiang 2019 []14 | NA (patient 11) | Abdominal pain | NA | Surgery | NA | NA | AWD (75 months) |
| Chiang 2019 []14 | NA (patient 12) | NA | NA | Surgery | NA | NA | NED (1 month) |
| Chiang 2019 []14 | 43 (patient 13) | NA | NA | Surgery | NA | NA | NA |
| Chiang 2019 []14 | 27 (patient 14) | Pelvic mass | NA | Surgery | NA | NA | NA |
| Chiang 2019 []14 | 56 (patient 15) | Pelvic mass | NA | Surgery | NA | NA | LTF |
| Chiang 2019 []14 | 56 (patient 16) | Pelvic mass | NA | Surgery | NA | NA | LTF |
| Chiang 2019 []14 | 55 (patient 17) | Abdominal pain, pelvic mass | NA | Surgery | NA | NA | LTF |
| This case | 58 | Abdominal| pain | SCC Ag: WNL | TH BSO → pelvic exenteration | Posterior wall of the uterine wall, extending into the uterine cervix Posterior cul-de-sac diaphragm | Recurrence after 3 weeks | DOD (7 months) |
| TH – total hysterectomy; USO – unilateral salpingo-oophorectomy; DOC – died of other cause; NA – not applicable; BSO – bilateral salpingo-oophorectomy; NED – no evidence of disease; CA125 – cancer antigen 125; DOD – died of disease; SCC Ag – squamous cell carcinoma antigen; WNL– within normal limit. | |||||||