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16 May 2023: Articles

Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report

Challenging differential diagnosis, Unusual setting of medical care, Rare disease

Ji Yeon Kim D , Bomi Kim A*

DOI: 10.12659/AJCR.939349

Am J Case Rep 2023; 24:e939349

Table 1. Summary of published cases of uterine leiomyosarcoma with rhabdoid features.

SourceAgeSymptomsTumor markertreatmentSite of the uterusRecurrence or metastasisFollow-up (time)
Yorulmaz 2007 []12 56AbdominalCA125 and CEA: WNLTH BSO palliative CT→mass excision, omentectomy, and left nephrectomy, adjuvant CT and RTUterine massRecurrence within 2 yearsDOD (2 years)
Hiraizumi 2011 []23 36NACA125: ↑LEEP, adjuvant CT →TH BSO, CTUterus, pelvic cavity, uterusMetastasis to urinary bladder, liver and spleenDOD (22 months)
Chauhan 2017 []27 60Abdominal mass and dull lower abdominal painNATH BSOMyometriumNANA
Kubo 2017 []16 52Abdominal fullnessCA125 and CA19-9: WNLTH, Adjuvant CTAnterior wall of the uterine cervixnoneNED (3 months)
Chiang 2019 []14 43 (patient 1)Abdominal massNASurgery, CT, and RTNANAAWD (180 months)
Chiang 2019 []14 36 (patient 2)Painful menses, pelvic massNASurgeryNANANED (9 months)
Chiang 2019 []14 56 (patient 3)Abdominal pain, pelvic painNASurgeryNANALTF
Chiang 2019 []14 42 (patient 4)Symptomatic fibroidsNASurgeryNANANED (96 months)
Chiang 2019 []14 41 (patient 5)Uterine massNASurgeryNANAAWD (75 months)
Chiang 2019 []14 55 (patient 6)Uterine massNASurgeryNANANED (1 months)
Chiang 2019 []14 NA (patient 7)Symptomatic fibroidsNASurgeryNANANA
Chiang 2019 []14 40 (patient 8)NANASurgery, CTNANANA
Chiang 2019 []14 82 (patient 9)Uterine massNASurgeryNANALTF
Chiang 2019 []14 45 (patient 10)Pelvic massNASurgeryNANANED (96 months)
Chiang 2019 []14 NA (patient 11)Abdominal painNASurgeryNANAAWD (75 months)
Chiang 2019 []14 NA (patient 12)NANASurgeryNANANED (1 month)
Chiang 2019 []14 43 (patient 13)NANASurgeryNANANA
Chiang 2019 []14 27 (patient 14)Pelvic massNASurgeryNANANA
Chiang 2019 []14 56 (patient 15)Pelvic massNASurgeryNANALTF
Chiang 2019 []14 56 (patient 16)Pelvic massNASurgeryNANALTF
Chiang 2019 []14 55 (patient 17)Abdominal pain, pelvic massNASurgeryNANALTF
This case58Abdominal| painSCC Ag: WNLTH BSO → pelvic exenterationPosterior wall of the uterine wall, extending into the uterine cervix Posterior cul-de-sac diaphragmRecurrence after 3 weeksDOD (7 months)
TH – total hysterectomy; USO – unilateral salpingo-oophorectomy; DOC – died of other cause; NA – not applicable; BSO – bilateral salpingo-oophorectomy; NED – no evidence of disease; CA125 – cancer antigen 125; DOD – died of disease; SCC Ag – squamous cell carcinoma antigen; WNL– within normal limit.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923