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16 May 2023: Articles

Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report

Challenging differential diagnosis, Unusual setting of medical care, Rare disease

Ji Yeon Kim D , Bomi Kim A*

DOI: 10.12659/AJCR.939349

Am J Case Rep 2023; 24:e939349

Table 2. Summary of pathological and genetic findings of patients with leiomyosarcoma with rhabdoid differentiation.

CaseMyxoidMicrocystic/alveolar patternMitosis (/10 HPF)CellSmooth muscle markerSkeletal muscle markerOthersGenetic alteration
Yorulmaz 2007 []12 NNNASSMA(+)MGB(+)CK(−)NA
RHSMA(+)MGB(+)D(+), CK(F+)
Hiraizumi 2011 []23 NNNumerousSSMA(+)MGB(F+)NA
Chauhan 2017 []27 YN10SNANANANA
Kubo 2017 []16 NN4RHA(+), HHF35(+), h-CD (+)NAD(−), CK(−)rearrangement from t(10;17)(q22;p13) and rearrangement
RA(+),HHF35(+),h− CD (+)NAD(−), CK(−)
Chiang 2019 []14 YNA19SNANAD(+)fusion
Chiang 2019 []14 YNA9SNANAD(+)fusion
Chiang 2019 []14 YNA4SNANAD(+)fusion
Chiang 2019 []14 NNA12RHNANAD(+)rearrangement
Chiang 2019 []14 NNA10SNANAD(+)fusion
Chiang 2019 []14 NNA10SNANAD(+)rearrangement
Chiang 2019 []14 NNA4SNANAD(−)None
Chiang 2019 []14 NNA13SNANAD(+)None
Chiang 2019 []14 NNA10SNANAD(+)None
Chiang 2019 []14 NNA1RHNANAD(+)None
Chiang 2019 []14 NNA13RHNANAD(+)None
Chiang 2019 []14 NNA2SNANAD(+)None
Chiang 2019 []14 NNA8SNANAD(+)none
Chiang 2019 []14 NNA5RHNANAD(−)None
Chiang 2019 []14 NNA6SNANAD(+)None
Chiang 2019 []14 NNA9SNANAD(+)None
Chiang 2019 []14 YNA5SNANAD(+)None
This caseNY30SSMA(−),SMMHC(−)MG(F+), MGB(−)D(F+)amplification, amplification, amplification, amplification, amplification, amplification, mutation (c.1303C>T), amplification, amplification, mutation (c.524G>A), amplification, amplification, amplification, and amplification
RHSMA(F+), SMMHC(−)MG(F+), MGB(−)D(F+)
ESMA(−),SMMHC(−)MG(F+), MGB(F+)D(F+)
N – no; NA – not applicable; HPF – high-power field; S – spindle cell; SMA – smooth muscle actin; ‘+’ – positive; MGB – myoglobin; CK – cytokeratinl ‘–‘ – negative; NA – not applicable; RH – rhabdoid cell; D – desmin; F+ – focally positive; Y – yes; R – round cell; A – actin; h-CD – h-caldesmon; SMMHC – smooth muscle myosin heavy chain; MG – myoglobin.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923