16 May 2023: Articles
Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report
Challenging differential diagnosis, Unusual setting of medical care, Rare disease
Ji Yeon Kim D , Bomi Kim A*DOI: 10.12659/AJCR.939349
Am J Case Rep 2023; 24:e939349
Table 2. Summary of pathological and genetic findings of patients with leiomyosarcoma with rhabdoid differentiation.
| Case | Myxoid | Microcystic/alveolar pattern | Mitosis (/10 HPF) | Cell | Smooth muscle marker | Skeletal muscle marker | Others | Genetic alteration |
|---|---|---|---|---|---|---|---|---|
| Yorulmaz 2007 []12 | N | N | NA | S | SMA(+) | MGB(+) | CK(−) | NA |
| RH | SMA(+) | MGB(+) | D(+), CK(F+) | |||||
| E | SMA(+) | CK(F+) | ||||||
| Hiraizumi 2011 []23 | N | N | Numerous | S | SMA(+) | MGB(F+) | NA | |
| Chauhan 2017 []27 | Y | N | 10 | S | NA | NA | NA | NA |
| R | ||||||||
| Kubo 2017 []16 | N | N | 4 | RH | A(+), HHF35(+), h-CD (+) | NA | D(−), CK(−) | rearrangement from t(10;17)(q22;p13) and rearrangement |
| R | A(+),HHF35(+),h− CD (+) | NA | D(−), CK(−) | |||||
| Chiang 2019 []14 | Y | NA | 19 | S | NA | NA | D(+) | fusion |
| RH | ||||||||
| Chiang 2019 []14 | Y | NA | 9 | S | NA | NA | D(+) | fusion |
| RH | ||||||||
| Chiang 2019 []14 | Y | NA | 4 | S | NA | NA | D(+) | fusion |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 12 | RH | NA | NA | D(+) | rearrangement |
| Chiang 2019 []14 | N | NA | 10 | S | NA | NA | D(+) | fusion |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 10 | S | NA | NA | D(+) | rearrangement |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 4 | S | NA | NA | D(−) | None |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 13 | S | NA | NA | D(+) | None |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 10 | S | NA | NA | D(+) | None |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 1 | RH | NA | NA | D(+) | None |
| Chiang 2019 []14 | N | NA | 13 | RH | NA | NA | D(+) | None |
| Chiang 2019 []14 | N | NA | 2 | S | NA | NA | D(+) | None |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 8 | S | NA | NA | D(+) | none |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 5 | RH | NA | NA | D(−) | None |
| Chiang 2019 []14 | N | NA | 6 | S | NA | NA | D(+) | None |
| RH | ||||||||
| Chiang 2019 []14 | N | NA | 9 | S | NA | NA | D(+) | None |
| RH | ||||||||
| Chiang 2019 []14 | Y | NA | 5 | S | NA | NA | D(+) | None |
| RH | ||||||||
| This case | N | Y | 30 | S | SMA(−),SMMHC(−) | MG(F+), MGB(−) | D(F+) | amplification, amplification, amplification, amplification, amplification, amplification, mutation (c.1303C>T), amplification, amplification, mutation (c.524G>A), amplification, amplification, amplification, and amplification |
| RH | SMA(F+), SMMHC(−) | MG(F+), MGB(−) | D(F+) | |||||
| E | SMA(−),SMMHC(−) | MG(F+), MGB(F+) | D(F+) | |||||
| N – no; NA – not applicable; HPF – high-power field; S – spindle cell; SMA – smooth muscle actin; ‘+’ – positive; MGB – myoglobin; CK – cytokeratinl ‘–‘ – negative; NA – not applicable; RH – rhabdoid cell; D – desmin; F+ – focally positive; Y – yes; R – round cell; A – actin; h-CD – h-caldesmon; SMMHC – smooth muscle myosin heavy chain; MG – myoglobin. | ||||||||