Endometrial Adenocarcinoma with Discordant Microsatellite Stability Status Treated with First-Line Pembrolizumab: A Case Report and Narrative Review

Christopher R. Grant; Elaine J. Chiao; Zhaohui L. Arter; Cary Johnson; Truc Tran; Farshid Dayyani; Krishnasu Tewari; Valery Vilchez; Joseph Carmichael; May Cho

doi:10.12659/AJCR.939448

29 June 2023 : Case report USA

Endometrial Adenocarcinoma with Discordant Microsatellite Stability Status Treated with First-Line Pembrolizumab: A Case Report and Narrative Review

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare coexistence of disease or pathology

Christopher R. Grant^1ABCDEF*, Elaine J. Chiao^1EF, Zhaohui L. Arter^2ADE, Cary Johnson^3C, Truc Tran^3BE, Farshid Dayyani^2E, Krishnasu Tewari^2E, Valery Vilchez^4E, Joseph Carmichael

^4E, May Cho^2ABCDE

DOI: 10.12659/AJCR.939448

Am J Case Rep 2023; 24:e939448

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Background Case Report Discussion Conclusions References:

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Table 1. Immunohistochemical stain and next-generation sequencing for microsatellite instability.

Specimen	Mismatch repair atatus
Tissue immunohistochemistry – primary endometrial carcinoma from uterus	Proficient
Caris next-generation sequencing – primary endometrial carcinoma	Quantity not sufficient
Tissue immunohistochemistry – recurrent retroperitoneal mass	Deficient
Guardant360 biomarker – serum after reoccurrence	Deficient
Caris next-generation sequencing – recurrent retroperitoneal mass	Deficient

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Endometrial Adenocarcinoma with Discordant Microsatellite Stability Status Treated with First-Line Pembrolizumab: A Case Report and Narrative Review

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