27 June 2023
: Case report 
Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma
Challenging differential diagnosis, Rare coexistence of disease or pathology
David Veríssimo1ABCDEF*, Joana Vinhais1BE, Catarina Rodrigues Ivo1DE, Isabel Sousa2BDE, Ana Cláudia Martins1DE, João Nunes e Silva1DE, Luís Lopes1DE, Dolores Passos1DE, João Jácome de Castro1DE, Mafalda Marcelino1DEDOI: 10.12659/AJCR.939659
Am J Case Rep 2023; 24:e939659
Table 1. Initial laboratory results.
| Analyte | Conventional units | International system | ||
|---|---|---|---|---|
| Result | Normal range | Result | Normal range | |
| Plasma renin activity (serum) | 0.2–1.6 | < 0.2 µg/L/hour | 0.2–1.6 | |
| Aldosterone (serum) | 26.8 ng/dL | 1–16 | 0.74 pmol/L | 0.03–0.44 |
| Aldosterone/plasma renin activity | 134 (ng/dL)/(ng/mL/h) | 3.72 (nmol/L)/(µg/L/h) | ||
| Potassium | 3.3 mEq/L | 3.5–5.5 | 3.3 mmol/L | 3.5–5.5 |
| Methanephrine (urine) | 474 µg/24h | 64–302 | 2403 nmol/day | 325–1531 |
| Normetanephrine (urine) | 1013 µg/24h | 162–527 | 5529 nmol/day | 884–2877 |
| 3-Methoxytiramine (urine) | 345 µg/24h | 30–434 | 1033 nmol/day | 90–1302 |
| Chromogranin A | 3.7 nmol/L | 0–5 | 3.7 nmol/L | 25–140 |
| ACTH | 6.4 pg/mL | 7.2–63.3 | 1.4 pmol/L | 1.5–14 |
| Cortisol (urine) | 5.6 µg/24h | 4.3–176 | 15.5 mmol/L | 11.9–486 |
| TSH | 2.19 µUI/ml | 0.35–4.94 | 2.19 mIU/L | 0.35–4.94 |
| FT4 | 0.88 ng/dL | 0.7–1.48 | 11.35 pmol/L | 9–19 |
| HbA1c | 8.0% | 63.9 mmol/mol | ||