02 September 2023
: Case report
A 65-Year-Old Man with Bilateral Adrenal Hemorrhage Following Prophylaxis for Postoperative Deep Vein Thrombosis with Rivaroxaban
Unusual clinical course, Challenging differential diagnosis
Safa Al-Rawi
DOI: 10.12659/AJCR.939816
Am J Case Rep 2023; 24:e939816
Table 3. Literature review of adrenal hemorrhage due to DOACs usage.
Author (yr) [reference] | Age/Sex | Presentation | DOAC duration | DOAC agent | DOAC dosage | Reason to get VTE prophylaxis | Laterality of AH | AI secondary to the AH |
---|---|---|---|---|---|---|---|---|
Comuth (2017) []13 | 63/Female | Abdominal pain | 5 months | Rivaroxaban | 20 mg daily | APLS | Bilateral | + |
Sanford (2019) []27 | 42/Male | Acute onset severe right flank pain | 4 weeks | Apixaban | Not reported | APLS | Unilateral | – |
Ly (2019) []22 | 61/Male | Nausea and vomiting | 14 days | Rivaroxaban | 10 mg daily | Knee surgery | Unilateral | – |
Alidoost (2019) []8 | 68/Female | Severe acute onset abdominal pain | 14 days | Rivaroxaban | 10 mg daily | Knee surgery | Bilateral | + |
Arosemena (2020) []26 | 46/Male | Syncopal episode | Few months | Rivaroxaban | Not reported | APLS | Bilateral | + |
Sheklabadi (2022) []14 | 35/Female | Nausea and vomiting and buccal hyperpigmentation | 1 year | Apixaban | 2.5 mg twice a day | IJVT | Unilateral | + |
Sheklabadi (2022) []14 | 89/Female | Fatigue and loss of appetite | 10 days | Rivaroxaban | 10 mg daily | Femur surgery | Bilateral | + |
Best (2013) []24 | 75/Female | Shortness of breath and fever | 9 days | Dabigatran | 150 mg daily | Hip surgery | Bilateral | + |
Elhassan (2022) []28 | 44/Female | Asymptomatic | Few days | Rivaroxaban | Not reported | APLS | Bilateral | + |
Current case (2022) | 65/Male | Nausea and severe acute onset abdominal pain | 10 days | Rivaroxaban | 10 mg daily | Knee surgery | Bilateral | + |
APLS – antiphospholipid syndrome; IJVT – internal jugular vein thrombosis; AH – adrenal hemorrhage; AI – adrenal insufficiency; DOAC – direct oral anticoagulant; VTE – venous thromboembolism. |