13 December 2023 : Case report
Unveiling the Rare Complication: Statin-Induced Immune-Mediated Necrotizing Myopathy
Unknown etiology, Challenging differential diagnosis, Rare disease, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Farheen Hussain Chowdhury1BCDEFG*, Olena Mahneva2ABCDEF, Maniekha Maharaj1BE, Werther Marciales1CGDOI: 10.12659/AJCR.941387
Am J Case Rep 2023; 24:e941387
Table 1. Creatine kinase, kidney and liver function enzymes, and blood glucose levels. The values were measured on different days of the patient’s hospitalization (days 1–13 of hospitalization, D1–13). The measurements were done throughout the first hospitalization (D1–10) and the second hospitalization (D12–13). Kidney function is represented by creatinine levels (Cr); liver function is represented by levels of the following enzymes: alkaline phosphatase (AP), aspartate transferase (AST), and alanine transaminase (ALT). Note: not every test was performed during each day of hospitalization. Creatine kinase (CK) values decreased with corticosteroid treatment and increased upon discontinuation. Kidney function was not reduced during the hospital stay. Liver function enzymes (AP, AST, and ALT) were elevated during the hospitalization; a reduction in the enzyme levels with corticosteroid treatment (D1 through D10) and an increase upon discontinuation was noted (D10 vs D12). The highest blood glucose level was noted on D8.
Test | D 1 | D 2 | D 3 | D 4 | D 5 | D 6 | D 7 | D 8 | D 9 | D 10 | D 12 | D 13 | Normal range |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CK (IU/L) | 12596 | 8285 | 5688 | – | – | 2953 | – | 3903 | 3032 | 2304 | 3190 | 1759 | 34–145 |
Cr (mg/dL) | 0.62 | 0.54 | 0.56 | 0.58 | 0.50 | 0.57 | 0.59 | 0.79 | 0.61 | 0.57 | 0.75 | 0.80 | 0.70–1.30 |
AP (U/L) | 76 | 69 | 69 | 58 | 64 | 62 | 67 | 83 | 68 | 63 | 72 | 70 | 46–116 |
AST (U/L) | 261 | 198 | 156 | 118 | 130 | 121 | 134 | 149 | 116 | 100 | 154 | 101 | 0–34 |
ALT (U/L) | 324 | 298 | 283 | 242 | 255 | 263 | 280 | 310 | 251 | 207 | 254 | 231 | 10–49 |
Glucose (mg/dL) | 137 | 94 | 87 | 83 | 81 | 82 | 82 | 231 | 88 | 93 | 85 | 129 | 74–106 |