13 December 2023
: Case report 
Unveiling the Rare Complication: Statin-Induced Immune-Mediated Necrotizing Myopathy
Unknown etiology, Challenging differential diagnosis, Rare disease, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Farheen Hussain Chowdhury1BCDEFG*, Olena Mahneva2ABCDEF, Maniekha Maharaj1BE, Werther Marciales1CGDOI: 10.12659/AJCR.941387
Am J Case Rep 2023; 24:e941387
Table 2. Complete blood counts. The CBC values were determined on different days of the patient’s hospitalization. The measurements were done throughout the first hospitalization (D1–10) and the second hospitalization (D12–13). WBC elevation starting on D2 may indicate reactive leukocytosis due to corticosteroid therapy.
| Test | D 1 | D 2 | D 3 | D 4 | D 5 | D 6 | D 7 | D 8 | D 9 | D 10 | D 12 | D 13 | Normal range |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WBC (cells/µl) | 8.54 | 11.01 | 12.61 | 10.41 | 12.21 | 14.03 | 11.71 | 16.64 | 14.05 | 17.15 | 14.55 | 24.12 | 4.3–11.0 ×10 |
| RBC (cells/µl) | 5.30 | 4.73 | 4.71 | 4.37 | 4.46 | 4.53 | 5.04 | 5.18 | 4.88 | 4.74 | 5.35 | 5.03 | 4.20–5.40 ×10 |
| Hgb (g/dL) | 15.4 | 13.5 | 13.7 | 12.6 | 13.0 | 13.4 | 14.4 | 15.4 | 14.1 | 13.6 | 15.5 | 15.1 | 12–16 |
| Hct (%) | 46.6 | 41.9 | 41.2 | 38.9 | 37.1 | 39.3 | 42.3 | 45.3 | 41.3 | 40.6 | 47.3 | 43.7 | 38–47 |
| MCV (fL) | 87.9 | 88.6 | 87.5 | 89.0 | 83.2 | 86.8 | 83.9 | 87.5 | 84.6 | 85.7 | 88.4 | 86.9 | 82–100 |
| MCH (pg) | 29.1 | 28.5 | 29.1 | 28.8 | 29.1 | 29.6 | 28.6 | 29.7 | 28.9 | 28.7 | 29.0 | 30.0 | 26–33 |
| MCHC (g/dL) | 33.0 | 32.2 | 33.3 | 32.4 | 35.0 | 34.1 | 34.0 | 34.0 | 34.1 | 33.5 | 32.8 | 34.6 | 31–33 |
| RDW-CV (%) | 13.7 | 13.6 | 13.8 | 14.1 | 13.9 | 14.3 | 14.2 | 15.0 | 14.7 | 14.4 | 15.5 | 15.0 | 11.5–14.5 |
| Pl (platelets/µl) | 267 | 231 | 233 | 217 | 200 | 240 | 284 | 299 | 244 | 268 | 288 | 274 | 150–375 ×10 |
| MPV (fL) | 10.8 | 10.7 | 10.9 | 10.3 | 11.1 | 10.2 | 10.3 | 10.3 | 10.6 | 10.1 | 10.1 | 10.3 | 8.6–11.7 |
| NRBC% | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| NRBC# (cells/µl) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 ×10 |
| D1–10 – the days of the first hospitalization from the day of admission until the day of initial discharge; D12–13 – the days of the second hospital re-admission; CBC – complete blood count; WBC – white blood cells; RBC – red blood cells; Hgb – hemoglobin; Hct – hematocrit; MCV – mean corpuscular volume; MCH – mean corpuscular hemoglobin; MCHC – mean corpuscular hemoglobin concentration; RDW-CV – red cell distribution width; Pl – platelets; MPV – mean platelet volume; NRBC% – nucleated red blood cell percentage; NRBC# – nucleated red blood cell number. | |||||||||||||