09 December 2023
: Case report 
Long-Term Indomethacin Treatment in a Chinese Child with Gitelman Syndrome: Case Report and Literature Review on its Efficacy and Tolerance
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease
Xiaoyan Peng1ABCEF, Chaoying Chen1AFG*, Juan Tu1DEF, Yuan Lin1BD, Huarong Li1BD, Haiyun Geng1BCDDOI: 10.12659/AJCR.941627
Am J Case Rep 2023; 24:e941627
Table 1. Clinical data of the patient over a 10-year period.
| Parameter/data | 4.8 yrs | 9.8 yrs | 11.8 yrs | 12.8 yrs | 14.8 yrs | Normal |
|---|---|---|---|---|---|---|
| Weight (kg) | 13 | 30 | 39 | 52 | 62 | – |
| Height (cm) | 97 | 131 | 149 | 154 | 161 | – |
| Blood pressure (mmHg) | 95/65 | 95/53 | 112/78 | 102/64 | 110/64 | – |
| Blood routine test | ||||||
| White blood cell count (×10/L) | 6.4 | 5.7 | 6.21 | 3.61 | 5.8 | 4∼10 |
| Red blood cell count (×10/L) | 5.0 | 5.1 | 5.36 | 5.20 | 5.36 | 3.5∼5.5 |
| Hemoglobin (g/L) | 130 | 140 | 161 | 158 | 160 | 120∼160 |
| Platelets (×10/L) | 298 | 302 | 160 | 289 | 342 | 100∼300 |
| Blood gas | ||||||
| pH | 7.494 | 7.46 | 7.47 | 7.406 | 7.456 | 7.35∼7.45 |
| Serum bicarbonate (mmol/L) | 25 | 28.4 | 28 | 27.1 | 28 | 22∼27 |
| BE (mmol/L) | 3.1 | 4.9 | 4.2 | 2.8 | 4.2 | −4∼2 |
| Serum electrolytes (mmol/L) | ||||||
| Sodium | 122 | 137 | 136 | 140 | 139 | 135∼145 |
| Potassium | 2.23 | 3.44 | 3.17 | 3.61 | 3.25 | 3.5∼5.5 |
| Magnesium | 0.87 | 0.66 | 0.54 | 0.63 | 0.62 | 0.66∼1.00 |
| Calcium | 2.28 | 2.44 | 2.32 | 2.32 | 2.48 | 2.25∼2.74 |
| Serum creatinine (umol/L) | 31 | 42.2 | 47.5 | 62.4 | 56.9 | 35.9∼73.5 |
| Urine routine test | Neg | Neg | Neg | Neg | Neg | – |
| urine Ca/Cr (mmol: mmol) | 0.12 | 0.018 | 0.016 | 0.005 | 0.003 | <0.21 |
| urine Pro/Cr (mg/ml: mg/ml) | 0.2 | 0.14 | 0.13 | 0.11 | 0.09 | <0.2 |
| 24 h urine potassium (mmol/d) | 69 | 50.9 | – | 169 | 77.6 | <25 |
| 24 h urine protein (mg/d) | 88 | 76.38 | – | 130 | 112 | <150 |
| eGFR(ml/min/1.73 m) | 110 | 112 | 113 | 89 | 101.79 | 90∼120 |
| CCR(ml/min/1.73 m) | 126 | 119 | 116 | 95 | 123.2 | 90∼120 |
| yrs – years old; Neg – negative; BE – residual base; Ca/Cr – calcium/creatinine ratio; Pro/Cr – protein/creatinine ratio; eGFR – estimated Glomerular Filtration Rate; CCR – Creatinine Clearance Rate. 1 eGFR was calculated from Schwartz formula. eGFR=”k” height(cm)/serum creatinine(umol/L), k=36.5. The unit was ml/min./1.73 m. 2 CCR=(Urine CrUrine Volume1.73)/(Serum Cr6024body surface). | ||||||