Long-Term Indomethacin Treatment in a Chinese Child with Gitelman Syndrome: Case Report and Literature Review on its Efficacy and Tolerance

09 December 2023: Articles

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease

Xiaoyan Peng ^A , Chaoying Chen ^A* , Juan Tu ^D , Yuan Lin ^B , Huarong Li ^B , Haiyun Geng ^B

DOI: 10.12659/AJCR.941627

Am J Case Rep 2023; 24:e941627

Table 1. Clinical data of the patient over a 10-year period.

Parameter/data	4.8 yrs	9.8 yrs	11.8 yrs	12.8 yrs	14.8 yrs	Normal
Weight (kg)	13	30	39	52	62	–
Height (cm)	97	131	149	154	161	–
Blood pressure (mmHg)	95/65	95/53	112/78	102/64	110/64	–
Blood routine test
White blood cell count (×10/L)	6.4	5.7	6.21	3.61	5.8	4∼10
Red blood cell count (×10/L)	5.0	5.1	5.36	5.20	5.36	3.5∼5.5
Hemoglobin (g/L)	130	140	161	158	160	120∼160
Platelets (×10/L)	298	302	160	289	342	100∼300
Blood gas
pH	7.494	7.46	7.47	7.406	7.456	7.35∼7.45
Serum bicarbonate (mmol/L)	25	28.4	28	27.1	28	22∼27
BE (mmol/L)	3.1	4.9	4.2	2.8	4.2	−4∼2
Serum electrolytes (mmol/L)
Sodium	122	137	136	140	139	135∼145
Potassium	2.23	3.44	3.17	3.61	3.25	3.5∼5.5
Magnesium	0.87	0.66	0.54	0.63	0.62	0.66∼1.00
Calcium	2.28	2.44	2.32	2.32	2.48	2.25∼2.74
Serum creatinine (umol/L)	31	42.2	47.5	62.4	56.9	35.9∼73.5
Urine routine test	Neg	Neg	Neg	Neg	Neg	–
urine Ca/Cr (mmol: mmol)	0.12	0.018	0.016	0.005	0.003
urine Pro/Cr (mg/ml: mg/ml)	0.2	0.14	0.13	0.11	0.09
24 h urine potassium (mmol/d)	69	50.9	–	169	77.6
24 h urine protein (mg/d)	88	76.38	–	130	112
eGFR(ml/min/1.73 m)	110	112	113	89	101.79	90∼120
CCR(ml/min/1.73 m)	126	119	116	95	123.2	90∼120
yrs – years old; Neg – negative; BE – residual base; Ca/Cr – calcium/creatinine ratio; Pro/Cr – protein/creatinine ratio; eGFR – estimated Glomerular Filtration Rate; CCR – Creatinine Clearance Rate. ¹ eGFR was calculated from Schwartz formula. eGFR=”k” height(cm)/serum creatinine(umol/L), k=36.5. The unit was ml/min./1.73 m. ² CCR=(Urine CrUrine Volume1.73)/(Serum Cr6024body surface).