25 November 2023
: Case report 
Primary Thymic Hodgkin Lymphoma Coexisting with Thymoma and Myasthenia Gravis: A Case Report
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease, Rare coexistence of disease or pathology
Sarah Almuqbil1BEF*, Amal AlHarbi1BEF, Fatimah S. Alzouri1BEF, Hatem Yazeed Elbawab2ABEF, Noor S. Alsafwani3BE, Zahra Alkhunaizy3BEDOI: 10.12659/AJCR.941792
Am J Case Rep 2023; 24:e941792
Table 1. Reported cases of myasthenia gravis associated with Hodgkin lymphoma.
| Case | Age | Sex | Myasthenia gravis | Anti-receptor Antibody | Hodgkin lymphoma presentation | Hodgkin lymphoma type | Hodgkin lymphoma Stage | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| Null et al, 1977 []5 | 19 | F | Generalized fatigue, hand weakness, difficulty chewing | – | Chest X-ray shows anterior mediastinal mass | Nodular sclerosing type | IA | Remission of both MG and HL | |
| Tranchant et al, 1993 []6 | 29 | F | Weakness of upper limbs, neck, and larynx | Negative | CT shows anterior mediastinal mass | Nodular sclerosing type | IIB | Remission of HL MG initially got worse then improved | |
| Ferrò et al, 2005 []7 | 52 | F | Generalized MG | Positive | CT and MRI show anterior mediastinal mass | Nodular sclerosing type | IIA | Remission of both MG and HL | |
| Ayadi- Kaddour et al, 2008 []8 | 22 | M | Asymptomatic (diagnosed by electromyo-graphy) | – | – | – | Remission of MG | ||
| Yousfi et al, 2021 []9 | 22 | F | Weakness, fatigue, and ptosis | Positive | CT shows anterior mediastinal mass | Mixed cellularity | IIIA | – | – |
| F – female; M – male; CT – computed tomography; MRI – magnetic resonance imaging; HL – Hodgkin lymphoma; MG – myasthenia gravis. | |||||||||