28 December 2023
: Case report 
IgA Vasculitis as a Potential Complication of Fourth-Line Chemotherapy with Tegafur/Gimeracil/Oteracil (S-1) in Advanced Non-Small Cell Lung Cancer: A Case Report
Rare coexistence of disease or pathology
Ryotaro Yoneoka1ABCDEF, Hajime Kasai234ABCDEF*, Aoi Hino2ABCDE, Ayumi Hayashi5BCDE, Atsushi Sasaki2BCDE, Masayuki Ota6BCDE, Katsuhiko Asanuma5DE, Takuji Suzuki2DEDOI: 10.12659/AJCR.941826
Am J Case Rep 2023; 24:e941826
Table 2. Previously reported cases of IgA vasculitis with lung cancer.
| No | Reporter, year [Ref] | Age | Sex | Histological type | Symptoms due to IgA vasculitis | Timing of diagnosis | Main treatment for lung cancer before and after IgA vasculitis diagnosis | Treatment for . IgA vasculitis | Outcome after diagnosis of IgA vasculitis |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cairns et al 1978 []3 | 63 | M | Sq | Rash, arthritis, renal symptoms | IgA vasculitis → malignancy (8 months) | None | None approximately | Died after 1.5 years |
| 2 | “ | 73 | M | Sq | Rash, arthritis, abdominal symptoms | IgA vasculitis → malignancy | Surgical resection | None | Died after 2 years |
| 3 | Hoffbrand et al 1978 []9 | 59 | M | Sq | Rash, edema, renal symptoms | IgA vasculitis → malignancy | Surgical resection | None | Remission |
| 4 | Mitchell et al 1979 []4 | 57 | M | Sq | Rash, abdominal symptoms, renal symptoms | IgA vasculitis → malignancy (22 months) | Surgical resection | Steroid, immuno-suppressant | Remission |
| 5 | Blanco et al 1997 []5 | NA | NA | SCLC | Unknown | Almost simultaneous | Chemotherapy | None | Unknown |
| 6 | Ponge et al 1998 []6 | 75 | M | SCLC | Rash, arthritis | IgA vasculitis → malignancy (8 months) | Chemorad-iotherapy (carboplatin + etoposide) | None | Remission |
| 7 | Garcia-Porrlia et al 1998 []8 | 67 | M | SCLC | Anemia, high serum IgA, proteinuria, hematuria | IgA vasculitis malignancy (8 days) | Unknown | Unknown | Unknown |
| 8 | Weiler-Bisig et al 2005 []7 | NA | NA | Esophageal cancer, Ad | Unknown | IgA vasculitis → malignancy (5 months) | Chemotherapy | Steroid | Unknown |
| 9 | Solans et al 2008 []11 | 58 | M | Ad, Meta (Liver) | Rash, arthritis, abdominal symptoms, renal symptoms | Almost simultaneous | Surgical resection | Steroid, IVIG | Remission |
| 10 | Mitsui et al 2008 []10 | 67 | F | Ad, Meta (Brain, Lung, Bone) | Unknown | IgA vasculitis → malignancy | Unknown | Unknown | Died after 17 months |
| 11 | “ | 69 | M | Hypopharynx (Sq) Lung cancer (histological type unknown) | Unknown | malignancy → IgA vasculitis | Unknown | Unknown | Bone metastasis after 1 month |
| 12 | Frigui et al 2009 []12 | 50 | M | Sq | Rash, arthritis, abdominal symptoms | IgA vasculitis → malignancy (6 months) | Chemora-diotherapy (vinorelbine + cisplatin) | Steroid pulse therapy, steroid administration | Remission |
| 13 | Mifune et al 2011 []2 | 61 | M | Ad | Rash, diarrhea (abdominal symptoms) | Malignancy → IgA vasculitis (1 month)) | None | Steroid | Died after 3 months |
| 14 | Ota et al 2018 []13 | 50 | M | Ad | Rash, abdominal symptoms | Malignancy → IgA vasculitis | Chemotherapy (docetaxel) | Steroid | Remission |
| 15 | Casafont-Solé et al 2020 []14 | 64 | M | Sq | Rash, edema, renal symptoms | Malignancy → IgA vasculitis | Chemotherapy (pembro-lizumab) | Steroid | Remission |
| 16 | Taoka et al 2021 []15 | 72 | M | Sq | Rash, renal symptoms | Malignancy → IgA vasculitis | Chemora-diotherapy (cisplatin + docetaxel) | Steroid | Remission |
| 17 | Philppe et al 2021 []16 | 59 | M | Sq | Rash, renal symptoms, fever | Malignancy → IgA vasculitis (10 days) | Chemora-diotherapy (vinorelbine + cisplatin) | Steroid | Remission |
| Our Case | 59 | M | Ad | Skin rash, abdominal symptoms | Malignancy → IgA vasculitis(22 months) | Chemotherapy (tegafur/gimeracil/oteracil) | Steroid | Died after 3 months | |
| Ad – adenocarcinoma; F – female; IgA – immunoglobulin A; IVIG – intravenous immunoglobulin; M – male; Meta – metastasis; NA – not applicable; SCLC – small cell lung cancer; Sq – squamous cell carcinoma. | |||||||||