16 April 2024
: Case report 
Nivolumab-Induced Cytokine Release Syndrome: A Case Report and Literature Review
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Francis Ntwali1ABCDEF*, Quentin Gilliaux2A, Patrick M. Honoré1ADOI: 10.12659/AJCR.941835
Am J Case Rep 2024; 25:e941835
Table 1. Cytokine release syndrome grading according to the Common Terminology Criteria for Adverse Events.
| CTCAE Term | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
|---|---|---|---|---|---|
| Cytokine release syndrome | Fever with or without constitutional symptoms | Hypotension responding to fluids; hypoxia responding to <40% O2 | Hypotension managed with 1 vasopressor; hypoxia requiring ≥40% O2 | Life-threatening consequences; urgent intervention indicated | Death |
| CTCAE – Common Terminology Criteria for Adverse Events. | |||||