05 February 2024
: Case report 
Pharmacogenetic Analysis of an 8-Year Old Girl with Reye Syndrome Associated with Use of Naproxen
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Unexpected drug reaction, Rare disease, Clinical situation which can not be reproduced for ethical reasons
Byungwook Kim
1ABDE, Joo-Youn Cho 1DE, Ildae Song 2EG*, Jaeseong Oh 3DEF
DOI: 10.12659/AJCR.942242
Am J Case Rep 2024; 25:e942242
Table 1. Clinical laboratory test results.
| Laboratory test result | Reference range | Hospitalization day | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 21 | 12 | 8 | 2 | 1* | −3 | −16 | −55 | ||
| AST (IU/L) | 1–40 | 27 | 26 | 24 | 955 | 909 | 76 | 1267 | 89 |
| ALT (IU/L) | 1–40 | 25 | 19 | 28 | 132 | 132 | 53 | 951 | 96 |
| BUN (mg/dL) | 10–26 | 23 | 58 | 39 | 45 | 52 | 6 | 10 | 8 |
| LDH (U/L) | 100–225 | 295 | – | 462 | 8040 | – | – | 1084 | 781 |
| Creatinine (mg/dL) | 0.5–1.0 | 0.66 | 2.32 | 1.21 | 2.00 | 2.76 | 0.50 | 0.48 | 0.47 |
| eGFR (mL/min/1.73 m) | – | 89.17 | 25.37 | 48.64 | 29.43 | 21.32 | 117.71 | 122.52 | 123.9 |
| Total Bilirubin (mg/dL) | 0.2–1.2 | 0.5 | 0.5 | 0.6 | 0.7 | 0.8 | 0.6 | 0.8 | 0.4 |
| Ammonia (ug/dL) | 18.7–86.9 | – | 45 | 44 | 88 | 93 | – | – | 43 |
| Ferritin (ug/L) | 4.6–204.7 | 1525.91 | – | 4007.96 | >40000.00 | >40000.00 | 2157.55 | 8360.80 | 16801.20 |
| *Day 1 marked the start date of neurologic symptoms of hypotension, tonic seizure, and loss of consciousness. ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; eGFR – estimated glomerular filtration rate; LDH – lactate dehydrogenase. | |||||||||