08 January 2024
: Case report
A 65-Year-Old Man Presenting to the Emergency Department with Gastric Hemorrhage Caused by a Glomus Tumor
Challenging differential diagnosis, Rare disease
Mariana Deacu12ABG, Madalina Bosoteanu12CD, Cristian-Ionut Orășanu
DOI: 10.12659/AJCR.942610
Am J Case Rep 2024; 25:e942610
Table 2. The main entities from which a gastric glomus tumor must be differentiated [27–31].
Frequent location | Endoscopic appearance | Gross appearance | Microscopic appearance | Immunohistochemistry | |
---|---|---|---|---|---|
Gastrointestinal stromal tumor | The fourth layer | Hypoechoic and homogeneous lesion | Nodular lesion | Spindle and epithelioid cells | CD117 +DOG1 + |
Leiomyoma | Layers 2, 3 or 4 | Hypoechoic and homogeneous lesion | Nodular lesion, well delimited, with a fasciculated appearance | Spindle cells with elongated nuclei and reduced atypia | SMA +Desmin + |
Carcinoid tumors | Layers 2 or 3 | Hypoechoic or isoechoic lesion, homogeneous | Nodular lesion, with slightly irregular edges | Round cells with round central nuclei | Chromogranin + |
Perivascular epithelioid cell tumor | Layers 2, 3 or 4 | Protrusive lesion | Nodular lesion, well defined | Epithelioid and/or spindle cells | HMB45 +Desmin +SMA + |
Hemangioma | Layer 2 | Hypoechoic lesion | Nodular, reddish, well-defined lesion | Vascular proliferations lined by endothelial cells | CD31 +CD34 +SMA + |