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01 June 2024 : Case report  Japan

Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report

Unusual clinical course

Tatsuya Yazaki12AEF*, Masanobu Kimoto1E, Ayumi Minagawa1E, Takashi Maruno1E, Miwa Yamanaka12E, Kei Sonehara2EF, Mineyuki Hama1E, Toshitsugu Nakamura3E, Shintaro Kanda4E, Masayuki Hanaoka2E, Tsutomu Hachiya1EF

DOI: 10.12659/AJCR.943466

Am J Case Rep 2024; 25:e943466

Table 1. Summary of epidermal growth factor receptor mutated lung adenocarcinomas with simultaneous T790M mutation and small cell lung carcinoma transformation and genetic testing results.

SourceAgeSexSmokingHistologyPathological stage
Tang K, et al []9 46FemalePassiveAdenocarcinomacT4N2M1b (stage IV) PUL, OSS
Hirata Y, et al []10 69FemaleNeverAdenocarcinomacT3N3M1b (stage IV) BRA, PUL
Current case80MaleCurrentAdenocarcinomapT2bN0M0 (stage IIA)
NGS – next-generation sequencing; EGFR ,– epidermal growth factor receptor; CT – computed tomography; PUL – pulmonary metastasis; OSS – bone; BRA – brain; – retinoblastoma susceptibility gene; – Catenin beta 1; – fibroblast growth factor receptor 2; – histidyl tRNA synthetase; – phosphatidylinositol-3-kinase gene symbol.
SourceDriver mutationDriver mutation after transformationNGS after transformationRecurrenceRe-biopsy
Tang K, et al []9 EGFR exon 19 deletionEGFR exon19 deletion, T790M mutation and RET mutationsPrimary mass, PUL, OSSBlood sample and CT-guided percutaneous lung biopsy
Hirata Y, et al []10 EGFR exon21 L858R mutationEGFR exon21 L858R mutation and T790M mutationUnknownPrimary massTransbronchial lung biopsy
Current caseEGFR exon21 L858R mutationEGFR exon21 L858R mutation and T790M mutationUnknownRight 6 and 7 ribsChest wall tumor resection
NGS – next-generation sequencing; EGFR ,– epidermal growth factor receptor; CT – computed tomography; PUL – pulmonary metastasis; OSS – bone; BRA – brain; – retinoblastoma susceptibility gene; – Catenin beta 1; – fibroblast growth factor receptor 2; – histidyl tRNA synthetase; – phosphatidylinositol-3-kinase gene symbol.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923