01 June 2024
: Case report
Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report
Unusual clinical course
Tatsuya Yazaki12AEF*, Masanobu Kimoto1E, Ayumi Minagawa1E, Takashi Maruno1E, Miwa Yamanaka12E, Kei Sonehara2EF, Mineyuki Hama1E, Toshitsugu Nakamura3E, Shintaro Kanda4E, Masayuki Hanaoka2E, Tsutomu Hachiya1EFDOI: 10.12659/AJCR.943466
Am J Case Rep 2024; 25:e943466
Table 1. Summary of epidermal growth factor receptor mutated lung adenocarcinomas with simultaneous T790M mutation and small cell lung carcinoma transformation and genetic testing results.
Source | Age | Sex | Smoking | Histology | Pathological stage |
---|---|---|---|---|---|
Tang K, et al []9 | 46 | Female | Passive | Adenocarcinoma | cT4N2M1b (stage IV) PUL, OSS |
Hirata Y, et al []10 | 69 | Female | Never | Adenocarcinoma | cT3N3M1b (stage IV) BRA, PUL |
Current case | 80 | Male | Current | Adenocarcinoma | pT2bN0M0 (stage IIA) |
NGS – next-generation sequencing; EGFR ,– epidermal growth factor receptor; CT – computed tomography; PUL – pulmonary metastasis; OSS – bone; BRA – brain; – retinoblastoma susceptibility gene; – Catenin beta 1; – fibroblast growth factor receptor 2; – histidyl tRNA synthetase; – phosphatidylinositol-3-kinase gene symbol. | |||||
Source | Driver mutation | Driver mutation after transformation | NGS after transformation | Recurrence | Re-biopsy |
Tang K, et al []9 | EGFR exon 19 deletion | EGFR exon19 deletion, T790M mutation and RET mutations | Primary mass, PUL, OSS | Blood sample and CT-guided percutaneous lung biopsy | |
Hirata Y, et al []10 | EGFR exon21 L858R mutation | EGFR exon21 L858R mutation and T790M mutation | Unknown | Primary mass | Transbronchial lung biopsy |
Current case | EGFR exon21 L858R mutation | EGFR exon21 L858R mutation and T790M mutation | Unknown | Right 6 and 7 ribs | Chest wall tumor resection |
NGS – next-generation sequencing; EGFR ,– epidermal growth factor receptor; CT – computed tomography; PUL – pulmonary metastasis; OSS – bone; BRA – brain; – retinoblastoma susceptibility gene; – Catenin beta 1; – fibroblast growth factor receptor 2; – histidyl tRNA synthetase; – phosphatidylinositol-3-kinase gene symbol. |