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01 June 2024 : Case report  Japan

Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report

Unusual clinical course

Tatsuya Yazaki12AEF*, Masanobu Kimoto1E, Ayumi Minagawa1E, Takashi Maruno1E, Miwa Yamanaka12E, Kei Sonehara2EF, Mineyuki Hama1E, Toshitsugu Nakamura3E, Shintaro Kanda4E, Masayuki Hanaoka2E, Tsutomu Hachiya1EF

DOI: 10.12659/AJCR.943466

Am J Case Rep 2024; 25:e943466

Table 2. Summary of treatments for each case.

Source1st line2nd line3rd line4th line5th line6th lineDuration of treatment after transformation
Tang K, et al []9 GefitinibOver 14 months
Hirata Y, et al []10 AfatinibCarboplatin + PemetrexedDocetaxelOver 8 months
Current caseErlotinibOver 25 months
Bold type indicates a treatment after small cell lung carcinoma transformation. Case 1 was treated for over 14 months, Case 2 was treated for over 8 months, and Case 3 (our case) was treated for over 25 months after the transformation of EGFR-positive lung adenocarcinoma to SCLC.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923