22 June 2024
: Case report
Blue Toe Syndrome in Behçet’s Disease: A Case Report
Unusual clinical course, Challenging differential diagnosis
Qusai Aljarrah

DOI: 10.12659/AJCR.943813
Am J Case Rep 2024; 25:e943813
Table 1. Blue toe syndrome differential diagnosis.
Blue toe syndrome | Raynaud’s phenomenon [33-36] | |
---|---|---|
Etiology | Auto-inflammatory/autoimmune | Stress/cold exposure |
Pathogenesis | Vasculitis | Vasospasm |
Structural changes | Micro- or macro-vascular structural changes | None |
Vessels affected | Small arteries proximal to digital arteries | Digital arteries |
Symmetry | More often Asymmetric | More often Symmetric |
Severity | More severe | Less severe |
Course | Usually progressive | Usually recurrent |
Inflammatory markers | Elevated | Normal |
Signs and symptoms | Pain and gangrene | Pain and triple-color change |
Treatment | Anti-inflammatories, anti-coagulants, anti-platelets, vasodilators | Usually self-limiting; vasodilators, anti-platelets |