15 July 2024
: Case report 
Severe Fatal ARDS Due to Untreated Human Granulocytic Anaplasmosis in a 67-Year-Old Man: A Case Report
Challenging differential diagnosis, Rare disease
Shehryar Malik1BEF, Martha F. Brucato2AF, Laura Faiver2BF, Tung Phan3E, Mohamed H. Yassin4B, Jonathan M. Bishop
2AD, Sumit Kapoor 2AEF*
DOI: 10.12659/AJCR.943966
Am J Case Rep 2024; 25:e943966
Table 1. Systemic complications and associations with human granulocytic anaplasmosis.
| Body system | Illnesses reported | References |
|---|---|---|
| Neurologic | Positive autoimmune encephalitis panel | Merati et al []11 |
| Meningo-encephalitis | Sohani et al []12 | |
| Expressive aphasia and bifrontal subarachnoid hemorrhage | Mullholand et al []13 | |
| Acute ischemic stroke | Kim et al []14 | |
| Dysarthria | Mir et al []15 | |
| Encephalopathy leading to trauma | Joshi et al []16 | |
| Focal Neurological deficits | Vanicek et al []17 | |
| Sensorineural hearing loss | Ghera et al []18 | |
| Respiratory | Pneumonitis | Yawetz et al [], Remy et al [], Tsibris et al [], Rivera et al [], Vyas et al [], Tasdemir et al [], Dumic et al []19 |
| ARDS | Koff et al [], Kaphle et al [], Patel et al []22 | |
| Cardiac | Acute myopericarditis | Rzechorzek et al [], Levy et al []28 |
| Myocarditis | Malik et al []30 | |
| Renal/urologic | AKI, rhabdomyolysis | Cho et al [], Boateng et al []31 |
| Rhabdomyolysis | Jawanda []33 | |
| Orchitis in renal transplant | Khatri et al []34 | |
| AKI, Acute membranoproliferative glomerulonephritis | Zhuo et al []35 | |
| Hematologic | Secondary HLH | Amri et al [], Rocco et al [], Scribner et al []36 |
| Splenomegaly and splenic rupture, hemoperitoneum | Hsia et al []40 | |
| Excess of gamma/delta T cells in bone marrow | Marko et al []41 | |
| Macrophage activation syndrome | Tsiodras et al []39 | |
| Rheumatologic | Inflammatory arthritis | Khoury et al []42 |
| Acute febrile neutrophilic dermatosis (Sweet syndrome) | Halasz et al []43 | |
| Musculoskeletal | Acute brachial plexitis | Helsen et al []44 |
| Ophthalmologic | Acute retinal hemorrhage | Lynch et al []45 |
| # indicate ‘associations’; ARDS – acute respiratory distress syndrome; AKI – acute kidney injury; HLH – hemophagocytic lymphohistiocytosis. | ||