Severe Fatal ARDS Due to Untreated Human Granulocytic Anaplasmosis in a 67-Year-Old Man: A Case Report

Shehryar Malik; Martha F. Brucato; Laura Faiver; Tung Phan; Mohamed H. Yassin; Jonathan M. Bishop; Sumit Kapoor

doi:10.12659/AJCR.943966

15 July 2024 : Case report USA

Severe Fatal ARDS Due to Untreated Human Granulocytic Anaplasmosis in a 67-Year-Old Man: A Case Report

Challenging differential diagnosis, Rare disease

Shehryar Malik^1BEF, Martha F. Brucato^2AF, Laura Faiver^2BF, Tung Phan^3E, Mohamed H. Yassin^4B, Jonathan M. Bishop

^2AD, Sumit Kapoor

^2AEF*

DOI: 10.12659/AJCR.943966

Am J Case Rep 2024; 25:e943966

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Table 2. Respiratory complications of human granulocytic anaplasmosis.

Case report, year [Ref]	Age (Years)	Gender	Travel/residence in endemicregions	Immuno-compromisedstate	Lungimaging	Diagnosis	Treatment	Mechanical ventilation	Outcome
Yawetzet al, 2001 []¹⁹	76	Male	Yes	No	Bilateral GGO and pleural effusions	ELISA for IgM, Ig G	Doxycycline	No	Recovery
Remy et al, 2003 []²⁰	47	Male	France	No	Bilateral Pneumonitis	Positive DNA PCR	Spiramycin, Cefpodoxime	No	Recovery
Tsibris et al, 2011 []²¹	77	Male	Yes	No	Left lung pneumonitis, pleural effusion	PositiveDNA PCR	Doxycycline	Tracheostomy	Recovery
Koff et al, 2013 []²²	49	Female	Yes	No	ARDS, bilateral interstitial opacities	PositiveDNA PCR	Doxycycline	3 days	Recovery
Kaphleet al, 2015 []²³	62	Male	Yes	No	ARDS,bilateralGGOs	PositiveDNA PCR	Doxycycline plussteroids	3 days	Recovery
Patel,2015 []²⁴	49	Female	Yes	No	ARDS,bilateral interstitial opacities	PositiveDNA PCR	Doxycycline	3 days	Recovery
Rivera, 2020 []¹⁰	70	Female	Yes	No	Bilateral pneumonitis, GGO	PositiveDNA PCR	Doxycycline	No	Recovery
Rivera, 2020 []¹⁰	63	Female	Yes	No	Bilateral pneumonitis, GGO	PositiveDNA PCR	Doxycycline	No	Recovery
Rivera, 2020 []¹⁰	64	Male	Yes	No	Bilateral pneumonitis, GGO	PositiveDNA PCR	Doxycycline	No	Recovery
Rivera, 2020 []¹⁰	78	Male	Yes	No	Bilateral pneumonitis, GGO	PositiveDNA PCR	Doxycycline	4 days	Recovery
Vyaset al, 2022 []²⁵	56	Female	Yes	No	bilateral GGO, small b/l pleural effusions	PositiveDNA PCR	Doxycycline	No	Recovery
Tasdemiret al, 2022 []²⁶	57	Male	Turkey	No	Bilateral Pneumonitis	PositiveDNA PCR	Doxycycline	No	Recovery
Dumicet al, 2023 []²⁷	78	Female	Yes	No	BilateralGGO	PositiveDNA PCR, positive IgG/IgM antibodies	Doxycycline	No	Recovery
Maliket al, 2024 (our case)	67	Male	Yes	No	ARDS,bilateral interstitial opacities	PositiveDNA PCR	Vancomycin, cefepime	4 days	Death
GGO – ground glass opacities; ELISA – enzyme linked immunosorbent assay; PCR – polymerase chain reaction; ARDS – acute respiratory distress syndrome.

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Severe Fatal ARDS Due to Untreated Human Granulocytic Anaplasmosis in a 67-Year-Old Man: A Case Report

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