Late-Onset Hemophagocytic Lymphohistiocytosis in a Lung Transplant Patient: A Case of T-Cell Post-Transplant Lymphoproliferative Disorder

Charline Leclercq; Pierre-Yves Sansen; Elodie Collinge; Robin Thirionet; Patrick Evrard; Thomas Planté-Bordeneuve; Caroline Fervaille; Marie Pouplard; Michel Dumonceaux; Anne Sonet; François M. Carlier

doi:10.12659/AJCR.944761

16 October 2024 : Case report Belgium

Late-Onset Hemophagocytic Lymphohistiocytosis in a Lung Transplant Patient: A Case of T-Cell Post-Transplant Lymphoproliferative Disorder

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Rare disease

Charline Leclercq^1BEF, Pierre-Yves Sansen^2DE, Elodie Collinge^2BE, Robin Thirionet^1BE, Patrick Evrard^3E, Thomas Planté-Bordeneuve^13E, Caroline Fervaille^4B, Marie Pouplard^5B, Michel Dumonceaux^13E, Anne Sonet^2E, François M. Carlier

^13ABCDEG*

DOI: 10.12659/AJCR.944761

Am J Case Rep 2024; 25:e944761

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Table 1. Main biological values at admission.

Readout	Value	Unit	Reference values

Hemoglobin	8.8	g/dL	12.0–15.8
Red blood cells	2,590×10	/µL	3500–5300×10
Hematocrit	26.3	%	33.0–46.0
Mean corpuscle volume	101.5	µm	80.1–99.8
Leukocytes	680×10	/µL	3,900–11,100×10
Neutrophils	530×10	/µL	2,100–7,500×10
Lymphocytes	20×10	/µL	1000–3000×10
Monocytes	130×10	/µL	0.240–0.910×10
Platelets	50×10	/µL	150–400×10
Reticulocytes	29×10	/µL	25.0–75.0×10
Schistocytes	0.33	%	<0.5%

Natrium	129	mmol/L	137–145
Potassium	4.6	mmol/L	3.5–5.1
Chloride	106	mmol/L	98–107
Bicarbonate	14	mmol/L	22–30
Calcium	2.16	mmol/L	2.10–2.55
Magnesium	0.54	mmol/L	0.66–0.94

Creatinine	2.76	mg/dL	0.52–1.04
Urea	99	mg/dL	15–36
Estimated glomerular flow rate	18.2	mL/min/1.73m
Total proteins	51.0	g/L	63.0–82.0
Albumin	31.7	g/L	35.0–50.0
Total bilirubin	0.55	mg/dL	0.00–1.30
Haptoglobin	1.28	g/L	0.34–2.00
Ferritin	724.0	µg/L	11.1–264.0
Fibrinogen	398	mg/dL	180–400

LDH	241	IU/L	120–246
Alkaline phosphatases	60	IU/L	38–126
Aspartate transaminase	16	IU/L	14–36
Alanine transaminase	11	IU/L	<35
Gamma-GT	10	IU/L	12–43
Creatine phosphokinase	<20	IU/L	30–135

Triglycerides	286	mg/dL	<150

Tacrolimus	9.40	ng/mL	8–10

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Late-Onset Hemophagocytic Lymphohistiocytosis in a Lung Transplant Patient: A Case of T-Cell Post-Transplant Lymphoproliferative Disorder

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