16 October 2024
: Case report 
Late-Onset Hemophagocytic Lymphohistiocytosis in a Lung Transplant Patient: A Case of T-Cell Post-Transplant Lymphoproliferative Disorder
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Rare disease
Charline Leclercq1BEF, Pierre-Yves Sansen2DE, Elodie Collinge2BE, Robin Thirionet1BE, Patrick Evrard3E, Thomas Planté-Bordeneuve13E, Caroline Fervaille4B, Marie Pouplard5B, Michel Dumonceaux13E, Anne Sonet2E, François M. Carlier
13ABCDEG*
DOI: 10.12659/AJCR.944761
Am J Case Rep 2024; 25:e944761
Table 2. Parameters relative to the H-Score over time.
| Date | IS | Max. (°C) | Organomegaly | Number of cytopenias | Ferritin (µg/L) | Triglyceride (mg/dL) | Fibrinogen (mg/dL) | AST (IU/L) | Bone marrow | H-score (%probability HLH) |
|---|---|---|---|---|---|---|---|---|---|---|
| 03/08 | Yes | 39.0 | NA | 3 | 724 | 286 | 398 | 16 | NA | 129 (5–9%) |
| 05/08 | Yes | 38.6 | NA | 3 | 992 | 294 | 340 | 23 | + | 164 (40–54%) |
| 08/08 | Yes | 39.4 | Spleen | 3 | 1520 | 485 | 179 | 24 | + | 237 (98–99%) |
| 11/08 | Yes | 37.4 | Spleen | 3 | 2110 | 468 | 173 | 21 | + | 239 (98–99%) |
| 14/08 | Yes | 37.5 | Spleen | 3 | 1560 | 409 | 135 | 22 | + | 204 (88–93%) |
| 17/08 | Yes | 37.3 | Spleen | 3 | 2270 | 361 | 175 | 18 | + | 239 (98–99%) |
| 20/08 | Yes | 38.2 | Spleen | 3 | 2090 | 379 | 116 | 21 | + | 239 (98–99%) |
| 22/08 | Yes | 39.1 | Spleen | 3 | 4170 | 421 | 116 | 23 | + | 272 (>99%) |
| 24/08 | Yes | 39.5 | Spleen | 3 | 16100 | 403 | 91 | 62 | + | 322 (>99%) |
| AST – aspartate transaminase; HLH – hemophagocytic lymphohistiocytosis; IU – international units; IS – immunosuppression; NA – not assessed. | ||||||||||