30 March 2025
: Case report 
Andexanet Alfa in Urgent Cardiac Surgery: A Case Report of Edoxaban Reversal for Acute Hemopericardium
Unusual clinical course, Management of emergency care
Mohammad Al Mawed ABDEF 1*, Helmut Warkentin ABCDEF 2, Johannes P. Brockmeier ABDE 1, René Schramm BE 3, Jan Gummert BCDF 3, Vera von Dossow ABCD 2, Stephan Gielen ABCDE 1DOI: 10.12659/AJCR.945265
Am J Case Rep 2025; 26:e945265
Table 2. Timetable.
| Admission to ward | 17.07.2021 01: 07 |
| Last edoxaban intake | 22.07.2021 07: 35 |
| Right-heart catheter beginning | 23.07.2021 10: 26 |
| 5000 i.e. heparin administration | 23.07.2021 10: 28 |
| Pressure drop | 23.07.2021 10: 48 |
| Noradrenaline i.v. application | 23.07.2021 10: 54 |
| Pericardiocentesis | 23.07.2021 11: 02 |
| 5000 i.e. protamine | 23.07.2021 11: 08 |
| 400 mg andexanet alfa | 23.07.2021 11: 18 |
| Intubation and ventilation | 23.07.2021 11: 48 |
| Air rescue take off | 23.07.2021 13: 10 |
| Air rescue landing | 23.07.2021 13: 20 |
| Anesthesia contact | 23.07.2021 13: 39 |
| Measurement of anti-Xa activity | 23.07.2021 14: 14 |
| Surgery start | 23.07.2021 14: 32 |
| Surgery end | 23.07.2021 17: 19 |
| Admission to ICU | 23.07.2021 17: 40 |
| Restart of anticoagulation in form of unfractionated heparin | 24.07.2021 07: 15 |
| Admission to ward | 27.07.2021 11: 02 |
| Discharge from hospital | 06.08.2021 11: 22 |