17 April 2025
: Case report 
Hypothyroidism and Double Mitral Lesion in Antiphospholipid Syndrome During Pregnancy: A Case Report
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Adverse events of drug therapy, Clinical situation which can not be reproduced for ethical reasons, Rare coexistence of disease or pathology
José Manuel Madrazo Cabo A 1,2, Ania Villavicencio Flores BE 2, Paulina Chagollán Gudiño BE 2, Nuvia Adriana Monter Valera F 2, Jose Antonio Velasco Bárcena D 3, Virginia Sedeño Monge E 2*DOI: 10.12659/AJCR.945578
Am J Case Rep 2025; 26:e945578
Table 1. Laboratory data.
| Variable (units) | Admission date (23/05/23) | Day 2 (24/05/23) | Day 3 (25/05/23) | Day 4 (26/05/2023) | Reference range for adults |
|---|---|---|---|---|---|
| D-dimer (ng/dl) | 1292.2 | 45–500 | |||
| Troponin I (pg/mL) | 2.80 | 16.60 | 13.30 | 12.70 | 0.00–15.60 |
| N-terminal pro-B-type natriuretic peptide (NT-proBNP) (pg/mL) | – | – | 0.0–116.0 | ||
| Type B natriuretic peptide (BNP) (pg/mL) | 72.6 | 105.7 | – | 0.0–100 | |
| Erythrocytes (10/µL) | 4.06 | 3.92 | 3.90 | 4.09 | 4.20–5.40 |
| Hemoglobin (g/dl) | 12.2 | 12 | 11.6 | 12.4 | 12–16 |
| Hematocrit (%) | 37.7 | 36.2 | 35.9 | 37.8 | 37–48 |
| Leucocytes (10/µL) | 10.7 | 9.9 | 3.8–11.2 | ||
| Absolute segmented neutrophils (10/µL) | 7.40 | 1.50–7.80 | |||
| Platelets (10/µL) | 209.6 | 201.8 | 212.4 | 211.7 | 130–400 |
| Glucose (mg/dl) | 93.0 | 103.0 | 103.0 | 87.0 | 74–99 |
| Urea nitrogen (BUN) (mg/dl) | 8.5 | 13 | 14.0 | 25.0 | 6.0–20 |
| Urea (mg/dl) | 18.2 | 27.8 | 30.0 | 53.5 | 14–55 |
| Creatinine (mg/dl) | 0.61 | 0.72 | 0.66 | 0.83 | 0.60–1.60 |
| Calcium (mg/dl) | 8.4 | 7.9 | 8.2 | 8.6 | 8.4–10.2 |
| Phosphorus (mg/dl) | 3.4 | 4.3 | 3.6 | 3.5 | 2.2–4.5 |
| Magnesium (mg/dl) | 1.6 | 1.6 | 1.8 | 1.8 | 1.6–2.6 |
| Sodium (mmol/L) | 135.0 | 136.0 | 138.0 | 137.0 | 135–145 |
| Potassium (mmol/L) | 3.5 | 3.5 | 3.6 | 4.0 | 3.5–5.1 |
| Chlorine (mmol/L) | 110.0 | 109.0 | 110.0 | 107.0 | 95–114 |
| Total CO2 (mmol/L) | 13.0 | 16.0 | 16.0 | 17.0 | 22–39 |
| Total proteins (g/dl) | 7.1 | 6.6 | – | – | 6.4–8.3 |
| Albumin (g/dl) | 3.9 | 3.5 | – | – | 3.5–5.0 |
| Globulin (g/dl) | 3.2 | 3.1 | – | – | 2.5–4.2 |
| Total bilirubin (mg/dl) | 0.60 | 0.70 | – | – | 0.20–1.20 |
| Direct bilirubin (mg/dl) | 0.20 | 0.20 | – | – | 0.00–0.50 |
| Indirect bilirubin (mg/dl) | 0.40 | 0.50 | – | – | 0.00–1.00 |
| Glutamic oxalacetic transaminase (AST) (U/L) | 21 | 14.0 | – | 5.0–34.0 | |
| Glutamic pyruvic transaminase (ALT) (U/L) | 35 | 27.0 | – | – | 0.0–55.0 |
| Total alkaline phosphatase (U/L) | 159 | 159.0 | – | – | 40–150 |
| Lactic dehydrogenase (U/L) | 204 | 146.0 | – | – | 125–243 |
| Gamaglutamyl transpeptidase (GGT) (U/L) | 30 | 32.0 | – | – | 9.0–36.0 |