03 January 2025
: Case report 
Anti-Estrogen Therapy Achieves Complete Remission and Stability in Recurrent Cervical Cancer: A Case Study
Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents
Mun-Kun Hong12ABCDEF, Ching-Hsing Chiang1BEF, Chiu-Hsuan Cheng
3BDE, Tang-Yuan Chu124ACDEF*
DOI: 10.12659/AJCR.946296
Am J Case Rep 2025; 26:e946296
Table 1. Timeline of the patient’s symptoms, diagnosis, treatment, and follow-up.
| Date | Month since first recurrence | Antiestrogen | SCC-Ag | Acessment |
|---|---|---|---|---|
| Apr. 09 | −12 | 1,2 | Vaginal bleeding, diagnosed as SCC by cervical biopsy | |
| May 09 | −11 | 1,3 | ||
| Jun. 09 | −9 | 1,4 | CCRT | |
| Jul. 09 | −8 | 0,8 | ||
| Oct. 09 | −5 | 0,4 | SCC-Ag came to nadir | |
| Mar. 10 | −1 | 0,3 | 23-Mar-10 First PET-CT indicated *first central recurrence of SCC (SUVmax: early: 4.59, delayed: 6.34). | |
| May. 10 | 0 | 1,1 | Cervical biopsies revealed necrotic debris | |
| Aug. 10 | 6 | Tamoxifen | 1,4 | |
| Nov. 10 | 9 | 0,9 | ||
| Oct. 11 | 20 | 1 | ||
| Feb. 12 | 24 | 1,7 | 1-Jun-12 2 PET-CT | |
| May 12 | 27 | 1,4 | ||
| Dec. 12 | 34 | 1,5 | ||
| Mar. 13 | 37 | 0,9 | ||
| Jun. 13 | 40 | 3,5 | Significant elevation of SCC-Ag indicating *2 recurence | |
| Sep. 13 | 43 | Change tamoxifen to Letrozole | 5,5 | |
| Oct. 13 | 44 | 6,9 | 27-Nov-13 3 PET-CT | |
| Jul. 14 | 53 | 1,6 | ||
| Oct. 14 | 56 | 1,7 | ||
| Dec. 14 | 58 | 2,1 | ||
| Jun. 15 | 69 | 3,1 | Died of noncancer-related pneumonia and acute decompensated heart failure | |
| SCC – squamous cervical carcinoma; CCRT – concurrent chemoradiotherapy; PET-CT – positron emission tomography-computed tomography. The exact date was shaded (left only month and year) to prevent identifacation of personal data. | ||||