15 March 2025
: Case report 
Incidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review
Challenging differential diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Michele Persico
ABCDEF 1*, Brent D. Weinberg BDE 2, Stewart G. Neill BDE 3, Hui-Kuo Shu E 4, Jim Zhong EG 4
DOI: 10.12659/AJCR.946592
Am J Case Rep 2025; 26:e946592
Table 1. World Health Organization (WHO) grading of Solitary Fibrous Tumors (SFT) and histological criteria for different grades according to the 2007, 2016 and 2021 WHO Classification of Central Nervous System Tumors.
| WHO Grade (2021) [4] | Grading histological criteria | WHO Grade (2016) [46] | WHO Grade (2007) [11] |
|---|---|---|---|
| WHO grade 1 SFT | <5/10 HPF | WHO grade I SFT/HPC | SFT |
| WHO grade 2 SFT | ≥5/10 HPF + absent necrosis | WHO grade II SFT/HPC | HPC |
| WHO grade 3 SFT | ≥5/10 HPF + necrosis | WHO grade III SFT/HPC | Anaplastic HPC |
| WHO – World Health Organization; SFT – solitary fibrous tumor; HPF – high-power field; HPC – hemangiopericytoma. | |||