26 May 2025
: Case report 
A 4-Week-Old Female Infant with Type 3 von Willebrand Disease Presenting with Nosebleeds and Uncontrolled Bleeding Following Surgical Frenectomy: A Clinical Case
Rare disease
Aleksandra Zima
ABCDEF 1,2*, Teresa Iwaniec CDE 3,4, Joanna Zdziarska BDE 5, Tomasz Sacha CDE 3,4, Zbigniew Żuber ADE 2,6
DOI: 10.12659/AJCR.946625
Am J Case Rep 2025; 26:e946625
Table 2 Results of coagulation tests on day 29 of life.
| Coagulation parameter | Result | Reference range |
|---|---|---|
| Prothrombin time | 13.3 s | 10.4–13.0 s |
| INR | 1.20 | 0.85–1.15 |
| APTT | 25.0–33.5 s | |
| Thrombin time | 21.0 s | 14.0–21.0 s |
| Fibrinogen | 2.4 g/L | 1.8–3.5 g/L |
| Factor VIII | 50.00–150.00% | |
| Factor IX | 50.00–150.00% | |
| Factor XI | 51.8% | 50.00–150.00% |
| Factor XII | 58.4% | 50.00–150.00% |
| Factor XIII | 109.1% | 50.00–150.00% |
| Von Willebrand factor (ristocetin cofactor activity assay) | 50.00–150.00% | |
| Von Willebrand factor (antigen) | 50.00–150.00% | |
| APTT – activated partial thromboplastin time; INR – international normalized ratio. | ||