23 March 2025
: Case report 
Early-Onset Autoimmune Hemolytic Anemia from Pembrolizumab in a Patient with Metastatic Lung Cancer: A Case Report
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Femi Williams Adeoye
ABCDEF 1,2*, Sanggeeta Surandran ABCDEF 2, Nida Jaffar ADEF 1, Shankari Serumadar ABCDE 3, Gulshad Begum ABCDE 1,2
DOI: 10.12659/AJCR.946630
Am J Case Rep 2025; 26:e946630
Table 1. Trend of selected laboratory test results during hospitalization and 2 weeks after discharge.
| Laboratory parameters | Day 1 | Day 2 | Day 4 | Day 5 | 2 weeks after discharge | Normal range | SI unit |
|---|---|---|---|---|---|---|---|
| Lactate | 4.2 | (–) | (–) | (–) | (–) | 0.4–2.2 | mmol/l |
| Hemoglobin | 45 | 67 | 86 | 93 | 114 | 130–180 | g/l |
| LDH | 1214 | (–) | (–) | 1128 | 860 | 240–480 | u/l |
| Bilirubin (total) | 61 (unconjugated 72%) | 54 | 26 | 16 | 9 | 0–21 | umol/l |
| INR | 1.4 | 1.3 | 1.1 | (–) | 1.1 | 0.8–1.2 | |
| Haptoglobin | <0.3 | <0.3 | (–) | (–) | (–) | 0.3–2.0 | g/l |
| Reticulocyte count | 261.7 (23.7%) | (–) | (–) | (–) | (–) | 50–100 | 10/l |
| Serum ferritin | 2441 | (–) | (–) | (–) | (–) | 15–300 | ng/ml |
| IgA | 6.5 | (–) | 6.3 | (–) | (–) | 0.8–4.0 | g/l |
| IgG | 17.8 | (–) | 18.4 | (–) | (–) | 6–16.0 | |
| IgM | 0.6 | (–) | 0.6 | (–) | (–) | 0.5–2.0 | |
| Complements | C3 1.0 | (–) | (–) | (–) | (–) | 0.9–1.80 | g/l |
| C4 0.12 | (–) | (–) | (–) | (–) | 0.14–0.54 | ||
| INR – international normalized ratio; LDH – lactate dehydrogenase; Ig – immunoglobulin; (–) – not tested. | |||||||