28 May 2025
: Case report 
Comparative Analysis of Pure VWF and VWF/FVIII Complex in Orthopedic Surgery for Type 2B von Willebrand Disease
Unusual setting of medical care, Rare disease
Pierre Chamouni
ABCDEF 1*, Virginie Barbay ABCDEF 1, Paul Billoir CD 2,3, Veronique Le Cam Duchez DF 1,2
DOI: 10.12659/AJCR.947187
Am J Case Rep 2025; 26:e947187
Table 1 Substitution of VWF concentrates and biological monitoring during 2 hip replacement operations in a patient with von Willebrand disease type 2B.
| First hip replacement (right side) With Wilfactin® | Second hip replacement (left side) With Voncento® | ||
|---|---|---|---|
| • Hb (g/dL) | 14.5 | 14.1 | |
| • Platelets (G/L) | 137 | 122 | |
| • FVIII (IU/dL) | 65 | ND | |
| • VWF: RCo (IU/dL) | 17 | ND | |
| 1 injection (39 IU: VWF/Kg) | 1 injection (35 IU VWF/Kg; 15 IU FVIII/Kg) | ||
| • Hb (g/dL) | 12.5 | 12.1 | |
| • Platelets (G/L) | 116 | 91 | |
| • FVIII (IU/dL) | 140 | 102 | |
| • VWF: RCo (IU/dL) | 150 | 106 | |
| H+10: 1 injection (39 IU VWF/Kg) | No injection | ||
| 1 injection (39 IU VWF/Kg) | 1 injection (35 IU VWF/Kg: 15 IU FVIII/Kg) | ||
| • Hb (g/dL) | ND | 11.8 | |
| • Platelets (G/L) | ND | 73 | |
| • FVIII (IU/dL) | ND | 142 | |
| • VWF: RCo (IU/dL) | ND | 148 | |
| 1 injection (39 IU VWF/Kg) | 1 injection (35 IU VWF/Kg: 15 IU FVIII/Kg) | ||
| 1 injection (39 IU VWF/Kg) | 1 injection (35 IU VWF/Kg: 15 IU FVIII/Kg) | ||
| 1 injection (39 IU VWF/Kg) | 1 injection (35 IU VWF/Kg: 15 IU FVIII/Kg) | ||
| 1 injection (39 IU VWF/Kg) | 1 injection (35 IU VWF/Kg: 15 IU FVIII/Kg) | ||
| • Hb (g/dL) | 11.6 | 11.6 | |
| • Platelets (G/L) | 71 | 87 | |
| • FVIII (IU/dL) | ND | 159 | |
| • VWF: Rco (IU/dL) | ND | 123 | |
| 1 injection (39 IU VWF/Kg) | 1 injection (35 IU VWF/Kg: 15 IU FVIII/Kg) | ||
| 1 injection (39 IU VWF/Kg) | 1 injection (35 IU VWF/Kg: 15 IU FVIII/Kg) | ||
| D – day; IU – international unit; ND – not done; Hb – hemoglobin (normal reference range: 13.0–17.5 g/dL); Platelet (normal reference range: 150–400 G/L); FVIII – Factor VIII (normal reference range: 50–150 UI/dL); VWF: RCo – von Willebrand Factor: Ristocetin cofactor; (normal reference range: 50–150 UI/dL). | |||