07 June 2025
: Case report 
Efficacy of Hepatic Artery Infusion Chemotherapy with Bevacizumab and Sintilimab in Advanced Hepatocellular Carcinoma: A Case Report
Unusual clinical course, Unusual or unexpected effect of treatment, Educational Purpose (only if useful for a systematic review or synthesis)
Chenguang Hua E 1, Shanhe Huang C 1, Bo Ding D 1, Junru Chen B 1, Chaofeng Ding AG 1*DOI: 10.12659/AJCR.947317
Am J Case Rep 2025; 26:e947317
Table 1 Literature review of advanced HCC with tumor thrombosis and metastasis.
| Case | Reference | Age (yrs) | Sex | Country | Size of tumor (cm) | Classification of HVTT | Classification of PVTT | Metastasis | Treatment | Follow-up (months) | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Ning Sun et al []43 | 52 | Male | China | 13.7 | Vv3 | No | Left adrenal gland | TACE + tkis + PD-1 inhibitor + RT | 34 | Alive with recurrence of left adrenal gland metastasis and metastasis of lymph nodes |
| 2 | Takamichi Igarashi et al []44 | 75 | Male | Japan | 1.5 | Vv3 | No | Right adrenal gland | Surgical resection | 8 | Death |
| 3 | Chuanchao He et al []45 | 56 | Male | China | 12 | Vv2 | Vp4 | Intrahepatic | Surgical resection | 20 | Alive with progression of metastasis |
| 4 | Dong Jin Joo et al []46 | 50 | Male | Korea | N/A | Vv3 | No | Lung | Concurrent chemo-radiotherapy + HAIC + lung resection, radio-frequency ablation (RFA) + TACE for HCC recurrence, finally living donor liver transplantation | 96 | Alive |
| 5 | Xin Luo et al []47 | 59 | Male | China | 10 | No | Vp3 | Intrahepatic | HAIC + Lenvatinib + sintilmab + TACE + PVE + conversion surgery | 9 | Alive |
| 6 | Min Kyung Park et al []48 | 43 | Male | Korea | 14 | No | Vp3 | Intrahepatic | Transarterial radio-embolization + atezolizumab + bevacizumab | N/A | Alive with new intrahepatic lesions |
| 7 | Hojung Jung et al []49 | 60 | Male | Korea | 8 | No | Vp3 | Right adrenal gland | TACE + radiotherapy + Conversion surgery | 96 | Alive |
| 8 | Hiroshi Wada et al []50 | 51 | Male | Japan | 6 | No | Vp4 | Intrahepatic+ lymph node | Reduction surgery + IFN-α + continuous hepatic arterial infusion of 5-FU | 56 | Alive |
| 9 | Masato Nakamura et al []51 | 54 | Male | Japan | N/A | No | Vp4 | Intrahepatic | Extended left lobectomy + intra-arterial 5-FU infusion chemotherapy with subcutaneous IFN-α | 32 | Alive with HCC recurrence |
| 10 | Dario Lorenzin et al []52 | 49 | Female | Italy | 9 | No | Vp2 | Lymph node | Sorafenib + adjuvant Yttrium-90 radio-embolization | 12 | Alive |
| 11 | Adélia Simão et al []53 | 60 | Male | Coimbra | 17 | Vv3 | No | Intrahepatic+ lung + left adrenal gland | Sorafenib | 36 | Alive |
| HCC – hepatocellular carcinoma. | |||||||||||