Successful Treatment of Multidrug-Resistant Tuberculous Meningitis in a Young Chinese Woman: A Case Study From Japan

16 August 2025 : Case report Japan

Unusual clinical course, Unusual setting of medical care

Michiho Tanaka

^{EF 1*}, Ryo Hasegawa

^{EF 2}, Kazuhiro Ishikawa

^{EF 1}, Nobuyoshi Mori

^{AEF 1}

DOI: 10.12659/AJCR.947502

Am J Case Rep 2025; 26:e947502

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Table 2 Central nervous system penetration and the possibility of feeding tube administration for anti-TB drugs.

Drug	Route	CNS	NG
AMK	IM or IV	± ~ +
AMPC/CVA	PO	−	×
Bedaquiline	PO	+++
Capreomycin	IM or IV	Insufficient data
Clofazimine	PO	Insufficient data	×
CS	PO	++	°
Delamanid	PO	No data
EB	PO	− ~ ±	°
Ethionamide	PO	+++	×
IPM/CS	IV	− ~ ±
INH, high dose	PO, IM, or IV	+++	°
KM	IM or IV	±
LVFX	PO or IV	++	°
LZD	PO or IV	++	°
MEPM	IV	+
MFLX	PO or IV	+	°
Para-aminosalicylic acid	PO	Insufficient data
Pretomanid	PO	No data
PZA	PO	+++	°
SM	IM or IV	±
Thioacetazone	PO	Insufficient data
AMK – amikacin; CNS – central nervous system; CS – cycloserine; EB – ethambutol; IM - intramuscular; IMP – imipenem; INH – isoniazid; IV – intravenous; KM – kanamycin; LVFX – levofloxacin; LZD – linezolid; MDR-TB – multidrug-resistant tuberculosis; MEPM – meropenem; MFLX – moxifloxacin; NG – nasogastric; PO – per oral administration; PZA – pyrazinamide; RFP – rifampicin; SM – streptomycin; TB – tuberculosis; TBM – tuberculous meningitis. CNS penetration rating: +++ = excellent, ++ = good, + = moderate, ± = low, − = poor to negligible.

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