29 September 2025
: Case report 
Severe Myoclonus Masking Thyroid Storm Following Etomidate Administration: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unexpected drug reaction, Educational Purpose (only if useful for a systematic review or synthesis)
Ting Wang ABCDEFG 1*, Yun Wang ABCDEFG 1, Xiaoning Zhu BCD 1DOI: 10.12659/AJCR.947735
Am J Case Rep 2025; 26:e947735
Table 5 Naranjo scale showing score in this case.
| Clinical question | Yes | No | NA | Result |
|---|---|---|---|---|
| Are there any previous solid reports on this reaction? | +1 | 0 | 0 | +1 |
| Did the adverse event occur after the suspected agent was administered? | +2 | −1 | 0 | +2 |
| Did the adverse reaction resolve once the drug had been stopped or a specific antagonist was administered? | +1 | 0 | 0 | +1 |
| Did the adverse reaction develop after the agent was re-administered? | +2 | −1 | 0 | 0 |
| Are there any additional reasons that could have caused the reaction? | −1 | +2 | 0 | −1 |
| Did the reaction reappear when a placebo was given? | −1 | +1 | 0 | 0 |
| Was the agent detected in any body fluid in toxic concentration? | +1 | 0 | 0 | 0 |
| Was the reaction worse when the dose was raised, or less severe when the dose was reduced? | +1 | 0 | 0 | 0 |
| Did the patient react similarly to the same or similar agents in earlier exposures? | +1 | 0 | 0 | 0 |
| Was the adverse event supported by objective evidence? | +1 | 0 | 0 | 0 |
| Total score 3 | ||||
| <1: doubtful, 1–4: possible, 5–8: probable, >9: definitive for adverse drug reaction | ||||