23 March 2026
: Case report 
Isolated Premature Menarche in a 17-Month-Old: A Case Report
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Dewi Rani Pelitawati
ABCDEFG 1*, Artha Falentin Putri Susilo ABCDEFG 1,2, Anita Rachmawati ABCDF 1,2, Wiryawan Permadi ABCDEFG 1,2, Putri Nadhira Adinda Adriansyah ABEF 1, Nabila Chantikarizky Hasanah ABCDEFG 1
DOI: 10.12659/AJCR.947844
Am J Case Rep 2026; 27:e947844
Table 2 Laboratory test results.
| Parameter | Result (unit) | Reference range | ||
|---|---|---|---|---|
| 12/31/2021 | 1/7/2022 | 2/8/2022 | ||
| Endocrine | ||||
| fT4 | 1.4 | 0.7–1.8 ng/dL | ||
| TSH | 5.7 (↑) | IU | ||
| FSH | 2.84 | 4.67 (↑) | <0.3 IU/mL | |
| Estradiol | <11.80 | 20.66 | <11.8–29.1 pg/mL | |
| LH | <0.07 (↓) | 0.1–6.0 IU/mL | ||
| PT | 25.9 s (↑) | 14.00 s | 12–16 s | |
| INR | 2.41 s (↑) | 1.01 s | 0.8–1.2 s | |
| aPTT | 52.6 s (↑) | 30.7 s | 21–41 s | |
| Concentration of ADP 10 μM | 89.1% (↑) | 34.04–66.48% | ||
| Concentration of ADP 5 μM | 90.3% (↑) | 28.84–52.68% | ||
| Concentration of ADP 2.5 μM | 90.0% (↑) | 8.80–36.60% | ||
| Concentration of ADP 1 μM | 24.6% (↑) | 0.00–20.44% | ||
| ADP – adenosine diphosphate; fT4 – free thyroxine; TSHs – thyroid-stimulating hormone; FSH – follicle-stimulating hormone; LH – luteinizing hormone; PT – prothrombin time; INR – international normalized ratio; aPTT – activated partial thromboplastin time. | ||||