13 June 2025
: Case report 
Accelerated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in Response to TMP-SMX: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Adverse events of drug therapy, Clinical situation which can not be reproduced for ethical reasons
Emily J. Sanchez ABCDEF 1*, Elizabeth A. Cheiky ABCDF 1DOI: 10.12659/AJCR.948217
Am J Case Rep 2025; 26:e948217
Table 3 Compares and contrasts skin involvement, onset, symptoms, and mortality of Stevens-Johnson syndrome (SJS), fixed-drug eruption (FDE), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.
| Feature | SJS | FDE | DRESS |
|---|---|---|---|
| Definition | A severe mucocutenaous reaction; characterized by widespread skin detachment and mucous membrane involvement | Localized, immune-mediated hypersensitivity reaction.Recurrent, sharply demarcated skin lesions that reappear at the same site upon subsequent exposure to offending drug | Severe drug-induced hypersensitivity reaction characterized by rash, fever, hematologic abnormalities (eosinophilia), and internal organ involvement |
| Skin Involvement | |||
| Onset | |||
| Symptoms | Flu-like symptoms, painful red or purplish skinBlisters, erosions, especially in mucosal regions (eyes, mouth, genitals) | Erythematous, edematous plaques that may blister.Pruritic, painful, or asymptomatic.Post-inflammatory hyperpigmentation after resolution of acute phase | Fever, rash, eosinophilia, lymphadenopathy, and multi-organ involvement (eg, liver, kidneys, lungs) |
| Mortality | |||
| This table was created using reference material sourced in the reference list. It is not meant to be the sole resource used in clinical practice, but instead a means of providing a single location to compare the 3 different clinical conditions. Adapted from: []. | |||