13 June 2025
: Case report 
Accelerated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in Response to TMP-SMX: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Adverse events of drug therapy, Clinical situation which can not be reproduced for ethical reasons
Emily J. Sanchez ABCDEF 1*, Elizabeth A. Cheiky ABCDF 1DOI: 10.12659/AJCR.948217
Am J Case Rep 2025; 26:e948217
Table 4 The European Registry of Severe Cutaneous Adverse Reactions to Drugs and Collection of Biological Samples (RegiSCAR) as it relates to this patient.
| Yes | No | Unknown | Patient | |
|---|---|---|---|---|
| ≥ | 0 | −1 | −1 | |
| ≥ | 1 | 0 | 0 | |
| 1 | 0 | 0 | ||
| 0 | ||||
| • ≥0.7×10 or ≥10% if leucopenia | 1 | −1 | − | |
| • ≥1.5×10 | 2 | |||
| • At least 2 of the following: edema, infiltration, purpura, scaling | 1 | −1 | 0 | |
| • Extent ≥50% of body surface area | 1 | 0 | 0 | |
| 0 | −1 | 0 | ||
| • One | 1 | 0 | ||
| • Two or more | 2 | |||
| ≥ | 1 | −1 | −1 | − |
| (1 point if at least 3 of the following tests are performed and are negative: HAV, HBV, HCV, mycoplasma, chlamydia, ANA, blood culture) | 1 | 0 | 0 | |
| A RegiSCAR-Group score of 5 indicates a definite case. Case 1: total of 5 points. DRESS – drug reaction with eosinophilia and systemic symptoms; HAV – hepatitis A virus; HBV – hepatitis B virus; HCV – hepatitis C virus; ANA – antinuclear antibodies. Adapted from: []. | ||||