16 July 2025
: Case report 
Endovascular Embolization in Acquired Hemophilia A: A Case Study Highlighting Diagnostic and Therapeutic Strategies
Challenging differential diagnosis, Management of emergency care, Rare disease
Michail Makris EF 1, Stavroula Bountola EF 2, Vasileios Patriarcheas EF 1, Anastasia Adamou
EF 1, Panagiota Tsiatsiou EF 3, Vasileios Perifanis EF 1, Christos Savopoulos EF 1, Georgia Kaiafa EF 1*
DOI: 10.12659/AJCR.948268
Am J Case Rep 2025; 26:e948268
Table 2 Mixing study showing, first, the correction of aPTT following mixing with normal pooled plasma and, second, the prolongation after 2 h incubation with normal pooled plasma, indicating the presence of inhibitor. The difference between the second and third measurements supports the presence of time- and temperature-dependent inhibitors, typical for acquired hemophilia A.
| Measurement type | aPTT (s) |
|---|---|
| Patient’s aPTT at admission | 136 s |
| Immediate aPTT after mixing with normal pooled plasma (NPP) | 60.0 s |
| aPTT after 2-h incubation with NPP at 37°C | 108.5 s |
| 30.0 s | |
| 136 s | |
| 30.0 s |