18 October 2025
: Case report 
Exploring Anti-TNF Therapy in Relapsing Polychondritis with Co-Existing Ulcerative Colitis: A Case Report and Literature Review
Unusual setting of medical care, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Safi G. Alqatari ABDEF 1, Abdullah A. Al-Abdulwahab ABDEF 1, Ibrahim A. Alhafid ABDEF 1, Abrar J. Alwaheed ABC 1, Methal I. AlBayat ABDF 2, Moath T. Alkhouzaie ABDEF 1, Mohammed A. Alhussain ABDEF 1, Reem S. AlSulaiman AEF 1*, Amal S. AlSulaiman ABCEF 1, Ahmed M. Abu Quren ABEF 3DOI: 10.12659/AJCR.948279
Am J Case Rep 2025; 26:e948279
Table 1 Laboratory investigations.
| CBC | WBC: 9200 cells/μL | HgB: 13.6 g/dL | MCV: 84.2 fL | MCH: 26.3 pg | Platelets: 306 000 cells/μl |
| LFT | AST: 23 U/L | ALT: 58 U/L | ALP: 104 U/L | GGTP: 148 U/L | |
| Total bilirubin: 0.2 mg/dL | Direct bilirubin: 0.1 mg/dL | Total protein: 7.2 g/dL | LDH: 294 U/L | ||
| RFT | BUN: 17 mg/dL | Creatinine: 0.85 mg/dL | Na: 140 mEq/L | K: 4 mEq/L | Cl: 103 mEq/L |
| Inflammatory markers | CRP: 1.14 mg/dL* | ESR: 58 mm/h* | |||
| Thyroid Function Tests | TSH: 0.57 μIU/mL | Free T4: 0.85 ng/dL | |||
| Serology | HIV: Negative | Syphilis: Negative | HSV: Negative | Hepatitis profile: Negative | |
| Immunology tests | Rheumatoid factor: Negative | ANA: Positive* | Anti-smooth muscle: Positive* | PR3: 50.8* | |
| ANCA: Negative | DsDNA: Negative | Anti-Smith Antibody: Negative | MPO: Negative | ||
| LKM-1: Negative | HLA-27: Negative | Cardiolipin IgG: Negative | Cardiolipin IgM: Negative | ||
| Serum ACE: Negative | Anti-endomysial IgA: Negative | ||||
| Stool workup | Fecal calprotectin: 846 μg/g | Stool ova and parasites: Negative | Stool culture: Negative | ||
| ACE – angiotensin converting enzyme; CBC – complete blood count; WBC – white cell count; HgB – hemoglobin; MCV – mean corpuscular volume; MCH – mean corpuscular hemoglobin; LFT – Liver Function Test; AST – aspartate aminotransferase; ALT – alanine aminotransferase; ALP – alkaline phosphatase; GGT – gamma-glutamyl transferase; LDH – lactate dehydrogenase; RFT – Renal Function Test; BUN – blood urea nitrogen; K – potassium; Na – sodium; Cl – chloride; HCO3 – bicarbonate; CRP – C-reactive protein; ESR – erythrocyte sedimentation rate; TSH – thyroid stimulating hormone; T4 – thyroxine; HIV – human immunodeficiency virus; HSV – herpes simplex virus; ASMA – anti-smooth muscle antibodies; PR3 – proteinase 3; ANCA – anti-neutrophilic cytoplasmic autoantibody. | |||||