18 October 2025
: Case report 
Exploring Anti-TNF Therapy in Relapsing Polychondritis with Co-Existing Ulcerative Colitis: A Case Report and Literature Review
Unusual setting of medical care, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Safi G. Alqatari ABDEF 1, Abdullah A. Al-Abdulwahab ABDEF 1, Ibrahim A. Alhafid ABDEF 1, Abrar J. Alwaheed ABC 1, Methal I. AlBayat ABDF 2, Moath T. Alkhouzaie ABDEF 1, Mohammed A. Alhussain ABDEF 1, Reem S. AlSulaiman AEF 1*, Amal S. AlSulaiman ABCEF 1, Ahmed M. Abu Quren ABEF 3DOI: 10.12659/AJCR.948279
Am J Case Rep 2025; 26:e948279
Table 2 Cases of relapsing polychondritis associated with UC within the last 20 years.
| Year | First Author | Age, sex | Therapy for UC | Symptoms of RP | Therapy for RP |
|---|---|---|---|---|---|
| 2024 []6 | Dilara | 31, Male | Oral and local mesalamine | Bilateral auricular chondritis, nasal chondritis, and polyarthritis | Prednisolone |
| 2023 []19 | Kojima | 51, Male | Mesalamine, azathioprine, prednisolone, and golimumab | Hyperemia of left eye, arthralgia, cough, bloody phlegm | Prednisolone + golimumab |
| 2021 []20 | Hanioka | 72, Male | Prednisolone+ mesalamine | Bilateral auricular redness, saddle nose, polyarthralgia and swelling | Prednisolone+ tocilizumab |
| 2019 []21 | Tajiri | 50, Female | Not mentioned | Laryngotracheal involvement | Prednisolone+ cyclosporin |
| 2014 []22 | Karmacharya | 20, Female | Azathioprine | Pain, swelling, and redness of the right ear | Prednisolone |
| 2014 []23 | Sinha | 46, Female | Mesalamine, azathioprine, prednisolone | Pain, swelling, and redness of both ears | Prednisolone |
| 2010 []24 | Almadi | 53, Female | Not mentioned | Fever, neck pain, and erythematous swelling of eyelids and nose | Prednisolone |
| UC – ulcerative colitis; RP – relapsing polychondritis. | |||||