15 September 2025
: Case report 
Extracorporeal Blood Purification with CytoSorb® Hemoadsorption in Valve Surgery for Infective Endocarditis: A Case Series
Rare disease
Živojin S. Jonjev
ABCDEF 1,2*, Anđela Božić BCF 3, Ilija Bjeljac BC 3, Jan Hrubik BC 3, Novica Kalinić BCF 2
DOI: 10.12659/AJCR.948318
Am J Case Rep 2025; 26:e948318
Table 1 Time course of laboratory examination during treatment.
| Parameter | Patient #10 h/12 h/24 h | Patient #20 h/12 h/24 h | Patient #30 h/12 h/24 h | Patient #40 h/12 h/24 h |
|---|---|---|---|---|
| WBC (×10/μL) | 16.2/14.1/11.2 | 5.1/7.4/7.1 | 16.0/12.4/10.8 | 9.3/8.1/7.9 |
| LYM% | 5.4/16.1/29.1 | 7.1/18.2/23.8 | 11.1/23.1/32.2 | 16.1/22.1/33.2 |
| CRP (mg/L) | 148.7/100.1/57.7 | 118.0/88.3/44.8 | 70.9/51.1/31.8 | 46.3/31.1/18.1 |
| PCT (ng/ml) | 0.5/0.3/0.2 | 0.3/0.3/0.2 | 0.4/0.3/0.3 | 0.3/0.3/0.1 |
| pH | 7.26/7.42/7.41 | 7.31/7.39/7.38 | 7.29/7.45/7.44 | 7.29/7.40/7.44 |
| Lactate (mmol/L) | 6.2/5.0/2.5 | 4.0/3.8/1.7 | 6.3/4.0/1.9 | 7.4/5.3/3.1 |
| Bilirubin (μmol/L) | 20.0/18.1/17.6 | 8.4/7.2/7.6 | 11.0/9.2/10.1 | 11.0/10.2/9.6 |
| SCr (μmol/L) | 180.0/91.1/89.2 | 51.0/59.1/54.2 | 123.0/101.0/86.0 | 85.0/76.0/65.0 |
| Na+ (mmol/L) | 133/145/141 | 139/141/140 | 143/141/140 | 137/145/145 |
| K+ (mmol/L) | 5.7/4.6/4.7 | 6.0/5.2/4.5 | 5.9/4.9/4.0 | 7.3/5.1/3.7 |
| Platelets (×10/μL) | 156/131/123 | 71/201/199 | 423/341/233 | 228/201/173 |
| LDH | 344/270/180 | 384/232/140 | 434/250/116 | 642/389/216 |
| AST/ALT (ULN) | 2.1/1.4/0.8 | 2.3/1.6/0.7 | 2.2/1.5/0.8 | 2.1/1.1/0.7 |
| Ventilation (hours)* | 109.3 vs 8.7±2.1 | 5.3 vs 8.7±2.1 | 6.1 vs 8.7±2.1 | 8.1 vs 8.7±2.1 |
| UV (ml) | 1400 | 1800 | 1750 | 1250 |
| Time of discharge (days) | 17 | 7 | 7 | 7 |
| * Comparative ventilation duration of 8.7±2.1 hours represents the average mechanical ventilation duration in all IE patients operated on in our institution. WBC – white blood count; LYM – lymphocytes; CRP – C-reactive protein; PCT – procalcitonin; SCr – serum creatinine; Pl – platelets; LDH – lactate dehydrogenase; AST/ALT – aspartate aminotransferase/alanine aminotransferase ratio; ULN – upper limit of normal; Ventilation – hours on ventilator vs average values; UV – ultrafiltration volume in the operating room. | ||||