25 August 2025
: Case report 
Rapid Progression of Primary Hepatic Neuroendocrine Carcinoma: A Case Report Demonstrating Drastic Oncological Behavior
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Rare disease, Adverse events of drug therapy
Rina Kobayashi BF 1, Tomohide Hori
ABCDEF 1*, Makoto Yamawaki CDF 2, Shigeki Nakayama DF 1, Satoru Umegae DF 1, Takao Iwanaga DF 1, Ryutaro Nishikawa D 1, Takahiro Shimoyama DF 1, Sakurako Suzuki F 1, Shinichiro Atsumi CDF 3, Hiroshi Hasegawa F 2, Shigehito Nakashima DF 2, Kunihiro Higuchi F 2, Kentaro Onishi F 2, Ryotaro Sakaguchi F 2, Shoichi Morita F 2, Haruka Miyao F 2, Saki Aota F 2, Hikaru Ohtani F 1, Takayuki Yamamoto ADF 1
DOI: 10.12659/AJCR.948500
Am J Case Rep 2025; 26:e948500
Table 1 WHO classification in 2019.
| Classification | Differentiation | Ki67 labeling index (%) | Mitosis (/2 mm2) |
|---|---|---|---|
| NET G1 | Well differentiated | <3 | <2 |
| NET G2 | Well differentiated | 3–20 | 2–20 |
| NET G3 | Well differentiated | >20 | >20 |
| NEC Small-cell type | Poorly differentiated | >20 | >20 |
| NEC Large-cell type | Poorly differentiated | >20 | >20 |
| MiNEN | Variable | Variable | Variable |
| MiNEN – mixed neuroendocrine-non-neuroendocrine neoplasm; NEN – neuroendocrine neoplasm; NET – neuroendocrine tumor; WHO – World Health Organization. | |||